3-((4aR, 10bR)-8,9-dimethoxy-1, 2,3, 4,4a, 10b-hexahydrophenanthridin-6-yl)-benzoic acid methyl ester | 667422-73-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-((4aR, 10bR)-8,9-dimethoxy-1, 2,3, 4,4a, 10b-hexahydrophenanthridin-6-yl)-benzoic acid methyl ester
• 英文别名: methyl 3-[(4aR,10bR)-8,9-dimethoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-6-yl]benzoate
• CAS: 667422-73-3
• 化学式: C₂₃H₂₅NO₄
• 分子量: 379.456
• InChiKey: NNUPKLCBQZWFLQ-VQIMIIECSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Novel phenanthridines
  申请人：Flockerzi Dieter

  公开号：US20060116518A1

  公开（公告）日：2006-06-01

  Compounds of a certain formula 1, in which R1, R2, R3, R31, R4, R5, R51, R6 and R7 have the meanings indicated in the description, are novel effective PDE4 inhibitors.

  某种化学式为1的化合物，其中R1、R2、R3、R31、R4、R5、R51、R6和R7的意义如说明中所示，是一种新的有效PDE4抑制剂。
• NOVEL PHENANTHRIDINES
  申请人：ALTANA Pharma AG

  公开号：EP1537086A2

  公开（公告）日：2005-06-08
• AMIDO-SUBSTITUTED 6-PHENYLPHENANTHRIDINES
  申请人：Nycomed GmbH

  公开号：EP1858880A1

  公开（公告）日：2007-11-28
• Amido-Substituted 6-Phenylphenanthridines
  申请人：Kautz Ulrich

  公开号：US20080214536A1

  公开（公告）日：2008-09-04

  Compounds of a certain formula (I) in which R1, R2, R3, R31, R4, R5, R51, R6 and R7 have the meanings indicated in the description, are novel effective PDE4 inhibitors.
• [EN] NOVEL PHENANTHRIDINES<br/>[FR] NOUVELLES PHENANTHRIDINES
  申请人：ALTANA PHARMA AG

  公开号：WO2004018431A2

  公开（公告）日：2004-03-04

  Compounds of a certain formula (1), in which R1, R2, R3, R31, R4, R5, R51, R6 and R7 have the meanings indicated in the description, are novel effective PDE4 inhibitors.