| 1454890-46-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• CAS: 1454890-46-0
• 化学式: C₂₂H₃₇NO₂
• 分子量: 347.541
• InChiKey: XIWPANWNHPLGTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.79
• 重原子数：
  25.0
• 可旋转键数：
  15.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  21.7
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  3-decyloxy-5-hydroxybenzyl alcohol 在 18-冠醚-6 、 potassium tert-butylate 、 potassium carbonate 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 为溶剂， 反应 37.83h， 生成
  参考文献：
  名称：

  Electrostatic Control of Peptide Side-Chain Reactivity Using Amphiphilic Homopolymer-Based Supramolecular Assemblies

  摘要：

  Supramolecular assemblies formed by amphiphilic homopolyrners with negatively charged groups in the hydrophilic segment have been designed to enable high labeling selectivity toward reactive side chain functional groups in peptides. The negatively charged interiors of the supramolecular assemblies are found to block the reactivity of protonated amines that would otherwise be reactive in aqueous solution, while maintaining the reactivity of nonprotonated amines. Simple changes to the pH of the assemblies' interiors allow control over the reactivity of different functional groups in a manner that is dependent on the plc of a given peptide functional group. The labeling studies carried out in positively charged supramolecular assemblies and free buffer solution show that, even when the amine is protonated, labeling Selectivity exists only when complementary electrostatic interactions are present, thereby demonstrating the electrostatically controlled nature of these reactions.

  DOI：

  10.1021/ja404940s