4-{(S)-1-[((S)-2-hydroxy-1-phenylethylcarbamoyl)methyl]propyl}benzoic acid methyl ester | 862855-70-7

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 4-{(S)-1-[((S)-2-hydroxy-1-phenylethylcarbamoyl)methyl]propyl}benzoic acid methyl ester
• 英文别名: methyl 4-[(3S)-1-[[(1S)-2-hydroxy-1-phenylethyl]amino]-1-oxopentan-3-yl]benzoate
• CAS: 862855-70-7
• 化学式: C₂₁H₂₅NO₄
• 分子量: 355.434
• InChiKey: JDCPIMRVMHZJEX-HNAYVOBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] ALPHA-4 INTEGRIN MEDIATED CELL ADHESION INHIBITORS FOR THE TREATMENT OR PREVENTION OF INFLAMMATORY DISEASES<br/>[FR] INHIBITEURS D'ADHERENCE CELLULAIRE RELAYEE PAR L'INTEGRINE ALPHA-4 DANS LE TRAITEMENT OU LA PREVENTION DE MALADIES INFLAMMATOIRES
  申请人：TANABE SEIYAKU CO

  公开号：WO2005075438A1

  公开（公告）日：2005-08-18

  The present invention relates to novel compounds of formula (I), processes for their preparation, compositions comprising them and their use in the treatment or prevention of diseases capable of being modulated by the inhibition of cell adhesion.

  本发明涉及公式（I）的新化合物，其制备方法，包含它们的组合物以及它们在治疗或预防可通过抑制细胞粘附而调节的疾病中的应用。
• Alpha-4 Integrin Mediated Cell Adhesion Inhibitors for the Treatment or Prevention of Inflammatory Diseases
  申请人：Ward Robert William

  公开号：US20080234301A1

  公开（公告）日：2008-09-25

  The present invention relates to novel compounds of formula (I), processes for their preparation, compositions comprising them and their use in the treatment or prevention of diseases capable of being modulated by the inhibition of cell adhesion.

  本发明涉及式(I)的新化合物，其制备方法，包含它们的组合物以及它们在治疗或预防能够通过细胞黏附抑制进行调节的疾病中的使用。
• ALPHA-4 INTEGRIN MEDIATED CELL ADHESION INHIBITORS FOR THE TREATMENT OR PREVENTION OF INFLAMMATORY DISEASES
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1737826A1

  公开（公告）日：2007-01-03