N-(2-羟基-4-甲氧基亚苄基)-1-丁胺 | 1030838-03-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: N-(2-羟基-4-甲氧基亚苄基)-1-丁胺
• 英文名称: N-(2-hydroxy-4-methoxybenzylidene)-1-butylamine
• 英文别名: 2-((E)-(butylimino)methyl)-5-methoxyphenol
• CAS: 1030838-03-9
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: KMFPAGQJOWVIHY-UKTHLTGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.62
• 重原子数：
  15.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  41.82
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  dysprosium(III) nitrate hexahydrate 、 N-(2-羟基-4-甲氧基亚苄基)-1-丁胺 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Rare-Earth-Containing Magnetic Liquid Crystals

  摘要：

  Rare-earth-containing metallomesogens with 4-alkoxy-N-alkyl-2-hydroxybenzaldimine ligands are reported. The stoichiometry of the complexes is [Ln(LH)(3)(NO3)(3)], where Ln is the trivalent rare-earth ion;(Y, La, and Pr to Lu, except Pm) and LH is the Schiff base. The Schiff base ligands are in the zwitterionic form and coordinate through the phenolic oxygen only. The three nitrate groups coordinate in a bidentate fashion. The X-ray single-crystal structures of the nonmesogenic homologous complexes [Ln(LH)(3)(NO3)(3)]where Ln = Nd(III), Tb(III), and Dy(III) and LH = CH3OC6H3(2-OH)CH=NC4H9, are described. Although the Schiff base Ligands do not exhibit a mesophase, the metal complexes do (SmA phase). The mesogenic rare-earth complexes were studied by NMR, IR, EPR, magnetic susceptibility measurements, X-ray diffraction,and molecular modeling. The metal complexes in the mesophase have a very large magnetic anisotropy, so that these magnetic liquid crystals can easily be aligned by an external magnetic field.

  DOI：

  10.1021/ja993351q
• 作为产物：
  描述：

  2,4-二羟基苯甲醛 在 potassium hydrogencarbonate 、 溶剂黄146 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 N-(2-羟基-4-甲氧基亚苄基)-1-丁胺
  参考文献：
  名称：

  Rare-Earth-Containing Magnetic Liquid Crystals

  摘要：

  Rare-earth-containing metallomesogens with 4-alkoxy-N-alkyl-2-hydroxybenzaldimine ligands are reported. The stoichiometry of the complexes is [Ln(LH)(3)(NO3)(3)], where Ln is the trivalent rare-earth ion;(Y, La, and Pr to Lu, except Pm) and LH is the Schiff base. The Schiff base ligands are in the zwitterionic form and coordinate through the phenolic oxygen only. The three nitrate groups coordinate in a bidentate fashion. The X-ray single-crystal structures of the nonmesogenic homologous complexes [Ln(LH)(3)(NO3)(3)]where Ln = Nd(III), Tb(III), and Dy(III) and LH = CH3OC6H3(2-OH)CH=NC4H9, are described. Although the Schiff base Ligands do not exhibit a mesophase, the metal complexes do (SmA phase). The mesogenic rare-earth complexes were studied by NMR, IR, EPR, magnetic susceptibility measurements, X-ray diffraction,and molecular modeling. The metal complexes in the mesophase have a very large magnetic anisotropy, so that these magnetic liquid crystals can easily be aligned by an external magnetic field.

  DOI：

  10.1021/ja993351q

文献信息

• Alcohol Uncaging with Fluorescence Reporting: Evaluation of <i>o</i>-Acetoxyphenyl Methyloxazolone Precursors
  作者：Nathalie Gagey、Matthieu Emond、Pierre Neveu、Chouaha Benbrahim、Bernard Goetz、Isabelle Aujard、Jean-Bernard Baudin、Ludovic Jullien

  DOI：10.1021/ol800284g

  日期：2008.6.1

  This paper evaluates a series of photolabile protecting groups with built-in fluorescence reporting. They rely on readily available o-acetoxyphenyl methyloxazolones as activated precursors. Alcohol substrates are easily caged. The resulting photoactivable esters exhibit large one- and two-photon uncaging cross sections. The alcohol substrates are quantitatively released in a 1:1 molar ratio with a

  本文利用内置的荧光报告评估了一系列对光不稳定的保护基。他们依靠现成的邻乙酰氧基苯基甲基恶唑酮作为活化的前体。酒精基质很容易笼罩。所得的可光活化的酯表现出大的单光子和双光子解开截面。醇底物与强荧光香豆素副产物以1：1摩尔比定量释放，该香豆素副产物用作定量底物递送的报告分子。
• 2-Hydroxy-4-methoxybenzaldehyde: A Potent Tyrosinase Inhibitor from African Medicinal Plants
  作者：Isao Kubo、Ikuyo Kinst-Hori

  DOI：10.1055/s-1999-13955

  日期：1999.2

  By bioassay-guided fractionation using mushroom tyrosinase (EC 1.14.18.1), 2-hydroxy-4-methoxybenzaldehyde was characterized as the principal tyrosinase inhibitor from three East African medicinal plants, the root of Mondia whitei (Hook) Skeels (Asclepiaceae), the root of Rhus vulgaris Meikle (Anacardiaceae), and the bark of Sclerocarya caffra Sond (Anacardiaceae). It inhibited the oxidation of L-3

  通过使用蘑菇酪氨酸酶（EC 1.14.18.1）进行生物测定指导的分馏，将2-羟基-4-甲氧基苯甲醛定性为三种东非药用植物的主要酪氨酸酶抑制剂。寻常型大叶黄杨（Anacardiaceae）的根和Sclerocarya caffra Sond（Anacardiaceae）的树皮。它抑制了蘑菇酪氨酸酶对L-3,4-二羟基苯丙氨酸（L-DOPA）的氧化，ID50为4.3微克/毫升（0.03 mM）。通过Lineweaver-Burk图分析的抑制动力学发现，这种简单的苯甲醛衍生物是这种氧化的混合型抑制剂，并以多种方式影响酶。基于发现这种有效的酪氨酸酶抑制剂，