（+）-6,6'-{[(1R，3R）-1,3-二甲基-1,3基]双（氧）}双[4,8-双（叔丁基）-2，10-二甲氧基-丙二醇 | 149646-83-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: （+）-6,6'-{[(1R，3R）-1,3-二甲基-1,3基]双（氧）}双[4,8-双（叔丁基）-2，10-二甲氧基-丙二醇
• 中文别名: (+)-6,6'-{[(1R,3R)-1,3 - 二甲基- 1,3 基]双(氧)}双[4,8 - 双(叔丁基)-2,10 - 二甲氧基-丙二醇
• 英文名称: (R,R)-Chiraphite
• 英文别名: 4,8-ditert-butyl-6-[(2R,4R)-4-(4,8-ditert-butyl-2,10-dimethoxybenzo[d][1,3,2]benzodioxaphosphepin-6-yl)oxypentan-2-yl]oxy-2,10-dimethoxybenzo[d][1,3,2]benzodioxaphosphepine
• CAS: 149646-83-3
• 化学式: C₄₉H₆₆O₁₀P₂
• 分子量: 877.0
• InChiKey: XMUZNZWRMNWOHX-FQLXRVMXSA-N

物化性质

• 比旋光度：
  +35.4° (c 1.0, CH2Cl2)
• 沸点：
  816.6±65.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  14.4
• 重原子数：
  61
• 可旋转键数：
  14
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  10

安全信息

• 危险类别码：
  R
• 危险性防范说明：
  P231,P222,P305+P351+P338,P403+P233,P422,P501
• 危险性描述：
  H315,H319,H335

文献信息

• Stabilization of a Hydroformylation Process
  申请人：Peterson R. Ronald

  公开号：US20080027248A1

  公开（公告）日：2008-01-31

  An improved hydroformylation process involving reacting one or more reactants, such as an olefin, with carbon monoxide and hydrogen in the presence of a hydroformylation catalyst, to produce a reaction product fluid comprising one or more products, preferably aldehydes; wherein said process is conducted in a region of the hydroformylation rate curve that is negative or inverse order in carbon monoxide, which is sufficient to prevent and/or lessen deactivation of the hydroformylation catalyst; and wherein total pressure is controlled at a predetermined target value and/or vent flow rate is controlled at a predetermined target value, by adjusting a flow of a carbon-monoxide containing inlet gas, so as to prevent and/or lessen cycling of process parameters, e.g., reaction rate, total pressure, vent flow rate, and/or temperature.
• HYDROFORMYLATION PROCESS WITH IMPROVED CONTROL OVER PRODUCT ISOMERS
  申请人：Eisenschmid Thomas C.

  公开号：US20100069680A1

  公开（公告）日：2010-03-18

  A continuous hydroformylation process for producing a mixture of aldehydes with improved flexibility and stability of a normal/branched (N/I) isomer ratio of the product aldehydes. The process involves reacting one or more olefinically-unsaturated compounds with carbon monoxide and hydrogen in the presence of an organopolyphosphite ligand and an organomonophosphite ligand, at least one of such ligands being bonded to a transition metal to form a transition metal-ligand complex hydroformylation catalyst; the process being conducted at a sub-stoichiometric molar ratio of organopolyphosphite ligand to transition metal, at a super-stoichiometric (>2/1) molar ratio of organomonophosphite ligand to transition metal, and at a carbon monoxide partial pressure in the inverse order region of the hydroformylation rate curve; and controlling and varying the isomer ratio by varying the concentration of organopolyphosphite ligand relative to transition metal.
• SYNTHESIS OF QUINAZOLINE COMPOUNDS
  申请人：Genentech, Inc.

  公开号：US20220081413A1

  公开（公告）日：2022-03-17

  Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.
• US7446231B2
  申请人：——

  公开号：US7446231B2

  公开（公告）日：2008-11-04
• US7863487B2
  申请人：——

  公开号：US7863487B2

  公开（公告）日：2011-01-04