Ethyl 8-chloro-6-fluoro-1-methyl-4-oxo-7-(3-trifluoroacetylamino-1-pyrrolidinyl)-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate | 132844-99-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Ethyl 8-chloro-6-fluoro-1-methyl-4-oxo-7-(3-trifluoroacetylamino-1-pyrrolidinyl)-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate
• 英文别名: ethyl 8-chloro-6-fluoro-1-methyl-4-oxo-7-[3-[(2,2,2-trifluoroacetyl)amino]pyrrolidin-1-yl]-1H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate
• CAS: 132844-99-6
• 化学式: C₂₀H₁₈ClF₄N₃O₄S
• 分子量: 507.893
• InChiKey: ZKGHPGJBTJOHOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• Thiazetoquinoline-3-Carboxylic acid derivative, method for preparation thereof, and a pharmaceutical composition comprising the same
  申请人：HOKURIKU PHARMACEUTICAL CO., LTD.

  公开号：EP0393538A2

  公开（公告）日：1990-10-24

  A thiazetoquinoline-3-carboxylic acid derivative represented by the general formula (I) wherein R₁ is a hydrogen atom or a lower alkyl group; R₂ is a fluorine atom or a chlorine atom; R₃ is a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a halogenated lower alkanoyl, or alkoxycarbonyl group; and R₄ is a hydrogen atom or a lower alkyl group, and a pharmacologically acceptable salt thereof, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for the treatment of an infectious disease by administering the same, are disclosed.

  通式(I)代表的噻唑喹啉-3-羧酸衍生物 其中 R₁ 是氢原子或低级烷基；R₂ 是氟原子或氯原子；R₃ 是氢原子、低级烷基、低级烷酰基、卤代低级烷酰基或烷氧基羰基；和 R₄ 是氢原子或低级烷基，本发明公开了其药理学上可接受的盐、其制备工艺、包含其的药物组合物，以及通过施用其治疗传染性疾病的方法。
• Optically active thiazetoquino-line-3-carboxylic acid compound, method for preparation thereof, and a pharmaceutical composition comprising the same
  申请人：HOKURIKU PHARMACEUTICAL CO., LTD.

  公开号：EP0465716A1

  公开（公告）日：1992-01-15

  An optically active thiazetoquinoline-3-carboxylic acid compound represented by the following formula (I): wherein R¹ is a hydrogen atom or a lower alkyl group; R² is a fluorine atom or a chlorine atom; R³ is a hydrogen atom, a lower alkanoyl group, a halogenated lower alkanoyl, or the residue of carboxylic acid ester; and C * represents an asymmetric carbon atom of S- or R-configuration, a pharmacologically acceptable salt thereof, and a method for preparing the compound are disclosed. Also disclosed are antibacterial agent, antineoplastic agent, and anti-AIDS virus agent comprising the same, a pharmaceutical composition for the treatment of bacterial infectious disease, tumor, and AIDS comprising an effective amount of the same.

  由下式（I）代表的光学活性噻唑喹啉-3-羧酸化合物： 其中 R¹ 是氢原子或低级烷基；R² 是氟原子或氯原子；R³ 是氢原子、低级烷酰基、卤代低级烷酰基或羧酸酯残基；C * 代表 S- 或 R- 构型的不对称碳原子，本发明公开了其药理学上可接受的盐及其制备方法。还公开了由其组成的抗菌剂、抗肿瘤剂和抗艾滋病病毒剂，以及由有效量的其组成的用于治疗细菌性传染病、肿瘤和艾滋病的药物组合物。
• US5126337A
  申请人：——

  公开号：US5126337A

  公开（公告）日：1992-06-30