methyl (2R,4S,5R,6R)-5-acetamido-2-chloro-6-[(1S,2R)-2,3-diacetyloxy-1-methoxypropyl]-4-methoxyoxane-2-carboxylate | 1400692-83-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl (2R,4S,5R,6R)-5-acetamido-2-chloro-6-[(1S,2R)-2,3-diacetyloxy-1-methoxypropyl]-4-methoxyoxane-2-carboxylate
• CAS: 1400692-83-2
• 化学式: C₁₈H₂₈ClNO₁₀
• 分子量: 453.874
• InChiKey: VLWRRFXEXDSEDR-AIVZJVSBSA-N

物化性质

• 沸点：
  587.2±50.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  136
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  methyl (2R,4S,5R,6R)-5-acetamido-2-chloro-6-[(1S,2R)-2,3-diacetyloxy-1-methoxypropyl]-4-methoxyoxane-2-carboxylate 在 N-碘代丁二酰亚胺 、 三氟甲磺酸 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 14.0h， 生成
  参考文献：
  名称：

  Highly specific and rapid glycan based amperometric detection of influenza viruses

  摘要：

  (4,7二甲氧基)Sα2,3Gal或(4,7二甲氧基)Sα2,6Gal被用于高度特异性和快速检测流感病毒。

  DOI：

  10.1039/c6sc03720h

文献信息

• Detection of Enzymes, Viruses, and Bacteria Using Glucose Meters
  作者：Amrita Das、Xikai Cui、Vasanta Chivukula、Suri S. Iyer

  DOI：10.1021/acs.analchem.8b02960

  日期：2018.10.2

  We also demonstrate that glucose oxidase or glucose dehydrogenase is not required because the paracetamol gets oxidized directly on the electrode surface. This indicates that test strips without glucose oxidase or dehydrogenase can be used, and we can detect analytes in the presence of high levels of background glucose. We demonstrate this unique nature of the assay to detect paracetamol in simulated

  我们开发了创新的检测方法，可以快速检测酶。携带扑热息痛或邻苯二酚的化合物暴露于其各自的酶时，会释放出扑热息痛或邻苯二酚，可以使用标准血糖仪对其进行检测。该方法用于检测多种分析物，包括酶（例如β-半乳糖苷酶和α-甘露糖苷酶）以及病原体（例如流感病毒，肺炎链球菌和大肠杆菌）迅速。所有分析物的检出限极低，并且与流感病毒在临床上相关。我们还证明，由于扑热息痛在电极表面直接被氧化，因此不需要葡萄糖氧化酶或葡萄糖脱氢酶。这表明可以使用没有葡萄糖氧化酶或脱氢酶的试纸，并且我们可以在存在高水平背景葡萄糖的情况下检测分析物。我们证明了这种检测方法的独特性质，可在模拟尿液和绵羊血液中检测扑热息痛，而不会干扰内在葡萄糖，这表明血糖仪可用于检测无葡萄糖分析物而无背景葡萄糖干扰。
• Synthesis of novel N-acetylneuraminic acid derivatives as substrates for rapid detection of influenza virus neuraminidase
  作者：Wei Yang、Xiaoyu Liu、Xiaoxia Peng、Pei Li、Tianxin Wang、Guihua Tai、X. James Li、Yifa Zhou

  DOI：10.1016/j.carres.2012.06.009

  日期：2012.10

  Two novel N-acetylneuraminic acid derivatives, luciferyl N-acetylneuraminic acid (1) and luciferyl 4,7-di-O-methyl-N-acetylneuraminic acid (2), were designed and synthesized as substrates for the rapid detection of influenza virus neuraminidase. The sensitivity and specificity of the assays with compound 1 or 2 as the substrate for detection of neuraminidases from influenza virus (H1N1 and H5N1) and bacteria (A. ureafaciens and C. perfringens) were evaluated. Compound 1 was sensitive to neuraminidases from both influenza virus and bacteria. Bioluminescent assays with this compound with H1N1 and H5N1 neuraminidases were approximately 20- and 16-fold more sensitive, respectively, than the fluorescent method with the commercial substrate 4-MUNANA. In contrast, compound 2 was only sensitive to the neuraminidases from influenza virus, showing approximately 10- and 8-fold greater sensitivity than 4-MUNANA for the detection of H1N1 and H5N1 neuraminidases, respectively. The data showed that compound 2 could be used in assays for detection of an influenza viral neuraminidase. (c) 2012 Elsevier Ltd. All rights reserved.