3-methyl-3-propoxybutane-1,2-diol | 1609086-61-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methyl-3-propoxybutane-1,2-diol
• 英文别名: 3-Methyl-3-propoxybutane-1,2-diol
• CAS: 1609086-61-4
• 化学式: C₈H₁₈O₃
• 分子量: 162.229
• InChiKey: XSQVEHSKHUSXKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙醇 、 (3,3-二甲基环氧乙烷基)甲醇 在 silver trifluoromethanesulfonate 、 二氯二氧化钨 作用下， 反应 1.0h， 以55%的产率得到3-methyl-3-propoxybutane-1,2-diol
  参考文献：
  名称：

  Tungsten-Catalyzed Regioselective and Stereospecific Ring Opening of 2,3-Epoxy Alcohols and 2,3-Epoxy Sulfonamides

  摘要：

  The first catalytic, highly C3-selective, stereosepecific ring-opening reaction of 2,3-epoxy alcohols and 2,3-epoxy sulfonamides has been accomplished. This process was efficiently promoted by W-salts, and the developed method was applicable to various epoxides with diverse N- and O-nucleophiles affording the products in good to excellent yields (up to 95%) and generally with high regioselectivities (C3:C2 up to >99:1).

  DOI：

  10.1021/ja5029809

文献信息

• Tungsten-Catalyzed Regioselective and Stereospecific Ring Opening of 2,3-Epoxy Alcohols and 2,3-Epoxy Sulfonamides
  作者：Chuan Wang、Hisashi Yamamoto

  DOI：10.1021/ja5029809

  日期：2014.5.14

  The first catalytic, highly C3-selective, stereosepecific ring-opening reaction of 2,3-epoxy alcohols and 2,3-epoxy sulfonamides has been accomplished. This process was efficiently promoted by W-salts, and the developed method was applicable to various epoxides with diverse N- and O-nucleophiles affording the products in good to excellent yields (up to 95%) and generally with high regioselectivities (C3:C2 up to >99:1).