2-(4-bromophenyl)-1-cyclohexyl-4,5-diphenyl-1H-imidazole | 1438122-52-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-bromophenyl)-1-cyclohexyl-4,5-diphenyl-1H-imidazole
• CAS: 1438122-52-1
• 化学式: C₂₇H₂₅BrN₂
• 分子量: 457.413
• InChiKey: SSNQZVHFJDIDRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.15
• 重原子数：
  30.0
• 可旋转键数：
  4.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  17.82
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  环己胺 、 对溴苯甲醛 、 联苯甲酰 在 碳酸氢铵 作用下， 以 水 为溶剂， 反应 4.0h， 以95%的产率得到2-(4-bromophenyl)-1-cyclohexyl-4,5-diphenyl-1H-imidazole
  参考文献：
  名称：

  Covalently anchored organic carboxylic acid on porous silica nano particle: A novel organometallic catalyst (PSNP-CA) for the chromatography-free highly product selective synthesis of tetrasubstituted imidazoles

  摘要：

  A novel organometallic catalyst (PSNP-CA) has been prepared by post synthesis grafting of -COOH functionalized organosilane on porous silica nano particle by using surface hydroxyl groups as anchor point. It was characterized by using an array of sophisticated analytical techniques like 13C CP MAS NMR, 29Si MAS NMR, CHN analysis, BET, HR TEM, XRD, TGA, FTIR and pH measurement. The leaching of the active site is greatly avoided as the organic moieties are covalently attached to the inorganic support. This is the first example of organocatalysis promoted by a -COOH functionalized porous silica nano particle for the chemoselective synthesis of densely substituted imidazoles. The molecular scaffolds which assimilate bio-active imidazole moiety may be worthwhile molecule from the biological point of view. All the other reported procedures led to the mixture of tri and tetra substituted imidazoles and their proportions were successfully evaluated from crude H-1 NMR spectra. Greenness of the process was well instituted as water was exploited as reaction medium. This catalyst retained its activity after having it exposed to ambient atmosphere for 10 days. There was no deteriorating effect of aerial oxygen or moisture towards the activity of the catalyst. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2013.03.024