N-(2-t-butoxycarbonylaminophenyl)-4-[1-[3-(morpholin-4-yl)propyl]-3-(quinolin-6-yl)ureidomethyl]benzamide | 1034495-75-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(2-t-butoxycarbonylaminophenyl)-4-[1-[3-(morpholin-4-yl)propyl]-3-(quinolin-6-yl)ureidomethyl]benzamide
• 英文别名: tert-butyl N-[2-[[4-[[3-morpholin-4-ylpropyl(quinolin-6-ylcarbamoyl)amino]methyl]benzoyl]amino]phenyl]carbamate
• CAS: 1034495-75-4
• 化学式: C₃₆H₄₂N₆O₅
• 分子量: 638.767
• InChiKey: MNGKZCZMESOQHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  47
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE
  申请人：Mogi Hiroyuki

  公开号：US20090306077A1

  公开（公告）日：2009-12-10

  The present invention relates to a study on the synthesis of a novel N-(2-aminophenyl)benzamide derivative having an urea structure and represented by the general formula (1); and the utilization of a pharmacological effect of the derivative. A compound represented by the general formula (1) or a salt thereof has an effect of cellular morphological change on trabecular meshwork cells and is effective in the prevention and/or treatment of a disease considered to be related to intraocular pressure. In the formula, R 1 and R 2 represent a hydrogen atom, a lower alkyl group, or the like; R 3 represents a hydroxy group, a lower alkoxy group, a lower cycloalkyloxy group, an aryloxy group, or the like; R 4 and R 5 represent a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, or the like; X represents a lower alkylene group or the like; Y represents a single bond, a lower alkylene group, or the like; l and m represent 0, 1, 2, or the like.

  本发明涉及一种关于合成一种新型N-(2-氨基苯基)苯酰胺衍生物的研究，其具有尿素结构，通式表示为(1)；以及利用该衍生物的药理作用。通式(1)或其盐具有对小梁网状组织细胞的细胞形态学改变作用，并在预防和/或治疗与眼压有关的疾病方面具有有效性。在公式中，R1和R2表示氢原子、较低的烷基或类似物；R3表示羟基、较低的烷氧基、较低的环烷氧基、芳基氧基或类似物；R4和R5表示卤原子、较低的烷基、羟基、较低的烷氧基或类似物；X表示较低的烷基亚基或类似物；Y表示单键、较低的烷基亚基或类似物；l和m表示0、1、2或类似物。
• NOVEL N-(2-AMINOPHENYL)BENZAMIDE DERIVATIVE HAVING AN UREA STRUCTURE
  申请人：Santen Pharmaceutical Co., Ltd

  公开号：EP2107052A1

  公开（公告）日：2009-10-07

  The present invention relates to a study on the sy nthesis of a novel N-(2-aminophenyl)benzamide derivativ e having an urea structure and represented by the genera l formula (1); and the utilization of a pharmacological effect of the derivative. A compound represented by the general formula (1) or a salt thereof has an effect of cellular morphological change on trabecular meshwork ce lls and is effective in the prevention and/or treatment of a disease considered to be related to intraocular pre ssure. In the formula, R1 and R2 represent a hydrogen a tom, a lower alkyl group, or the like; R3 represents a h ydroxy group, a lower alkoxy group, a lower cycloalkylo xy group, an aryloxy group, or the like; R4 and R5 repre sent a halogen atom, a lower alkyl group, a hydroxy grou p, a lower alkoxy group, or the like; X represents a low er alkylene group or the like; Y represents a single bon d, a lower alkylene group, or the like; l and m represen t 0, 1, 2, or the like.

  本发明涉及一种具有脲结构并由通式(1)表示的新型N-(2-氨基苯基)苯甲酰胺衍生物的合成研究；以及利用该衍生物的药理作用。通式（1）代表的化合物或其盐对小梁网细胞形态变化有影响，对预防和/或治疗被认为与眼压有关的疾病有效。式中，R1 和 R2 代表氢原子、低级烷基或类似基团；R3 代表羟基、低级烷氧基、低级环烷氧基、芳氧基或类似基团；R4 和 R5 代表卤素原子、低级烷基、羟基、低级烷氧基或类似基团；X 代表低级亚烷基或类似基团；Y 代表单骨架、低级亚烷基或类似基团；l 和 m 代表 0、1、2 或类似基团。
• US8076332B2
  申请人：——

  公开号：US8076332B2

  公开（公告）日：2011-12-13