(S)-2,2,4-trimethyl-4-(dimethoxymethyl)-1,3-dioxolane | 138835-00-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-2,2,4-trimethyl-4-(dimethoxymethyl)-1,3-dioxolane
• CAS: 138835-00-4
• 化学式: C₉H₁₈O₄
• 分子量: 190.24
• InChiKey: BJXYSOUUOXXJNP-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.15
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.92
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  (R)-ethyl 2,3-dihydroxy-2-methylpropionate 生成 (S)-2,2,4-trimethyl-4-(dimethoxymethyl)-1,3-dioxolane
  参考文献：
  名称：

  Optically active quaternary carbon centers from the photoaddition of chromium-alkoxycarbene complexes and optically active thiazolines

  摘要：

  The photolytic reaction of chromium-alkoxycarbene complexes with valine-derived, optically active thiazolines produced optically active beta-lactam penam derivatives in fair to good yield and with high diastereoselectivity. In most cases alcoholosis of the beta-lactam followed by solvolysis of the thiazolidine ring produced optically active quaternary centers having carbon substituents in four different oxidation states-alkane, alkoxy, aldehyde, and ester. The absolute configuration of the stereogenic center could be inverted by a sequence of redox manipulations of the ester and aldehyde group, making either enantiomer available from the same precursor.

  DOI：

  10.1021/jo00031a025