| 1015423-04-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1015423-04-7
• 化学式: C₂₇H₂₉FN₆O
• 分子量: 472.565
• InChiKey: WXEVYATZNZOKRY-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 2-溴丙烷 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 以35%的产率得到N-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)-5-propan-2-yloxypyrazolo[1,5-a]pyridin-7-amine
  参考文献：
  名称：

  Pyrazolopyridines with potent activity against herpesviruses: Effects of C5 substituents on antiviral activity

  摘要：

  Synthesis of a series of 5-substituted as well as 5,7-disubstituted 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-phenylpyrazolo [1,5-a]pyridin-7-amines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar to or better than acyclovir are described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.120
• 作为产物：
  描述：

  N-Cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-5-methoxypyrazolo[1,5-a]pyridin-7-amine 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 72.0h， 以66%的产率得到
  参考文献：
  名称：

  Pyrazolopyridines with potent activity against herpesviruses: Effects of C5 substituents on antiviral activity

  摘要：

  Synthesis of a series of 5-substituted as well as 5,7-disubstituted 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-phenylpyrazolo [1,5-a]pyridin-7-amines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar to or better than acyclovir are described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.120