triethyloxonium | 24935-24-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: triethyloxonium
• 英文别名: tetraethyloxonium；Tetraaethyloxonium；Triaethyloxonium；triethyl-oxonium cation；Triethyloxoniumion；triethyloxidanium
• CAS: 24935-24-8
• 化学式: C₆H₁₅O
• 分子量: 103.184
• InChiKey: DWCSXQCXXITVKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  triethyloxonium 、 (R)-1-(6,8,11-Trioxa-7-phospha-tricyclo[5.2.2.0^1,4]undec-4-yl)-methanol 生成
  参考文献：
  名称：

  Das, S. K.; Amma, P. Kumari; Vaidyanathaswamy, R., Phosphorus and Sulfur and the Related Elements, 1987, vol. 30, p. 301 - 304

  摘要：

  DOI：
• 作为产物：
  描述：

  重氮乙酸乙酯 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 作用下， 生成 triethyloxonium
  参考文献：
  名称：

  Klages et al., Justus Liebigs Annalen der Chemie, 1955, vol. 592, p. 81,113

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY<br/>[FR] DIHYDROPYRIMIDINONES BICYCLIQUES SUBSTITUÉES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE L'ACTIVITÉ ÉLASTASE DE NEUTROPHILES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2014135414A1

  公开（公告）日：2014-09-12

  This invention relates to substituted bicyclic dihydropyrimidinones of formula (1) and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.

  这项发明涉及式（1）的取代双环二氢嘧啶酮及其作为中性粒细胞弹性蛋白酶活性抑制剂的用途，含有这些化合物的药物组合物，以及将其用作治疗和/或预防肺部、胃肠道和泌尿系统疾病、皮肤和眼睛的炎症性疾病以及其他自身免疫和过敏性疾病、移植物排斥反应和肿瘤性疾病的药剂的方法。
• [EN] PREPARATION OF FLUOROSULFONATE ESTERS AND ONIUM SALTS DERIVED THEREFROM<br/>[FR] PRÉPARATION D'ESTERS DE FLUOROSULFONATE ET SELS D'ONIUM DÉRIVÉS DE CEUX-CI
  申请人：TRINAPCO INC

  公开号：WO2014124456A1

  公开（公告）日：2014-08-14

  The present invention is directed to methods for preparing a fluorosulfonate ester or a salt thereof, through a reaction of a dissolved sulfonyl fluoride (RFSO2F) with alkoxide anion (RO- ) optionally in the presence of an aprotic base (B), where RF is fluorine or a C1-C8 perfluoroalkyl group, and R is a primary alkyl or alkoxyalkyl. Alkoxide anion (RO-) can be generated from a precursor such as an alcohol or silyl ester.

  本发明涉及通过将溶解的磺酰氟化物（RFSO2F）与烷氧基阴离子（RO-）在有无无水碱（B）的情况下反应，制备氟磺酸酯或其盐的方法，其中RF为氟或C1-C8全氟烷基基团，R为一次烷基或烷氧基烷基。烷氧基阴离子（RO-）可以由醇或硅酯等前体生成。
• [EN] MTH1 INHIBITORS FOR TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS<br/>[FR] INHIBITEURS DE MTH1 DESTINÉS AU TRAITEMENT DES ÉTATS INFLAMMATOIRES ET AUTO-IMMUNS
  申请人：THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING

  公开号：WO2015187089A1

  公开（公告）日：2015-12-10

  A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

  化合物的化学式（I），或其药学上可接受的盐，用于治疗自身免疫性疾病和炎症性疾病。
• ATPENINS
  申请人：ADELT Isabelle

  公开号：US20100168175A1

  公开（公告）日：2010-07-01

  The present invention relates to processes for preparing certain 2-pyridones and 2-pyridinols, to novel compounds of these two types and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection, in the medicinal field and in the protection of materials.

  本发明涉及制备特定2-吡啶酮和2-吡啶醇的过程，涉及这两种类型的新化合物以及它们作为生物活性化合物的用途，特别是用于控制农作物保护中的有害微生物，在医药领域和材料保护中。
• [EN] NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES<br/>[FR] COMPOSÉS TRICYCLIQUES INNOVANTS SERVANT D'INHIBITEURS D'ENZYMES IDH MUTANTES
  申请人：MERCK SHARP & DOHME

  公开号：WO2016089797A1

  公开（公告）日：2016-06-09

  The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

  本发明涉及式(I)的三环化合物，该化合物是野生型异柠檬酸脱氢酶（IDH）抑制剂：(I)。本发明还涉及将此处描述的三环化合物用于潜在治疗或预防涉及一个或多个突变IDH酶的癌症。本发明还涉及包含这些化合物的组合物。本发明还涉及将这些组合物用于潜在预防或治疗此类癌症。