1-cyclohexyl-2-(2-fluoro-4-hydroxyphenyl)-1H-benzimidazole-5-carboxylic acid methyl ester | 501371-91-1
中文名称
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中文别名
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英文名称
1-cyclohexyl-2-(2-fluoro-4-hydroxyphenyl)-1H-benzimidazole-5-carboxylic acid methyl ester
英文别名
methyl 2-(2-fluoro-4-hydroxyphenyl)-1-cyclohexylbenzimidazole-5-carboxylate；Methyl 1-cyclohexyl-2-(2-fluoro-4-hydroxyphenyl)benzimidazole-5-carboxylate
CAS
501371-91-1
化学式
C21H21FN2O3
mdl
——
分子量
368.408
InChiKey
LTIJVHNEUMZYBO-UHFFFAOYSA-N
BEILSTEIN
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EINECS
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
计算性质
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辛醇/水分配系数(LogP)：4.4
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重原子数：27
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可旋转键数：4
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环数：4.0
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sp3杂化的碳原子比例：0.33
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拓扑面积：64.4
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氢给体数：1
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氢受体数：5
上下游信息
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下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— 2-[4-(biphenyl-2-ylmethoxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester —— C34H31FN2O3 534.63 —— 2-[4-(2-bromo-5-tert-butoxycarbonylbenzyloxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 808125-97-5 C33H34BrFN2O5 637.546 —— 1-cyclohexyl-2-[2-fluoro-4-(2-fluoro-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester 844893-02-3 C28H25F2N3O5 521.52 —— 2-[4-(2-bromo-5-nitrobenzyloxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 480461-26-5 C28H25BrFN3O5 582.426 —— methyl 2-(4-((5-amino-2-(4-chlorophenoxy)benzyl)oxy)-2-fluorophenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylate 943513-40-4 C34H31ClFN3O4 600.089 —— 2-[4-(5-amino-2-morpholin-4-ylbenzyloxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 844891-43-6 C32H35FN4O4 558.653 —— methyl 2-(4-((5-amino-2-(piperidin-1-yl)benzyl)oxy)-2-fluorophenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylate 943513-41-5 C33H37FN4O3 556.68 —— methyl 2-(4-((5-amino-2-(4-methylpiperazin-1-yl)benzyl)oxy)-2-fluorophenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylate 943513-44-8 C33H38FN5O3 571.695 —— 1-cyclohexyl-2-[2-fluoro-4-(5-isopropylamino-2-morpholin-4-ylbenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester 943513-60-8 C35H41FN4O4 600.733 —— 2-[4-(5-chloro-2-morpholin-4-ylbenzyloxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 943513-66-4 C32H33ClFN3O4 578.083 —— methyl 2-(4-((5-amino-2-(4-hydroxypiperidin-1-yl)benzyl)oxy)-2-fluorophenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylate 943513-42-6 C33H37FN4O4 572.68 —— 2-{4-[5-(acetylamino)-2-morpholin-4-ylbenzyloxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 844891-82-3 C34H37FN4O5 600.69 —— methyl 2-(4-((2-(4-acetylpiperazin-1-yl)-5-aminobenzyl)oxy)-2-fluorophenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylate 943513-45-9 C34H38FN5O4 599.705 —— 2-[4-(5-carboxy-2-morpholin-4-ylbenzyloxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 943513-22-2 C33H34FN3O6 587.648 —— methyl 2-(4-((2-(4-chlorophenoxy)-5-nitrobenzyl)oxy)-2-fluorophenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylate 943513-33-5 C34H29ClFN3O6 630.072 —— 1-(4-amino-2-((4-(1-cyclohexyl-5-(methoxycarbonyl)-1H-benzo[d]imidazol-2-yl)-3-fluorophenoxy)methyl)phenyl)piperidine-4-carboxylic acid 943513-43-7 C34H37FN4O5 600.69 —— 2-[4-(5-(acetyl)(methyl)amino-2-morpholin-4-ylbenzyloxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 844891-83-4 C35H39FN4O5 614.717 —— 2-{4-[5-(4-chlorobutyrylamino)-2-morpholin-4-ylbenzyloxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 943513-29-9 C36H40ClFN4O5 663.189 —— 2-[4-(5-tert-butoxycarbonyl-2-morpholin-4-ylbenzyloxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester 943513-62-0 C37H42FN3O6 643.755 —— methyl 1-cyclohexyl-2-(2-fluoro-4-((5-(2-methoxy-N-methylacetamido)-2-morpholinobenzyl)oxy)phenyl)-1H-benzo[d]imidazole-5-carboxylate 943513-69-7 C36H41FN4O6 644.743 —— methyl 1-cyclohexyl-2-(2-fluoro-4-((2-(4-methylpiperazin-1-yl)-5-nitrobenzyl)oxy)phenyl)-1H-benzo[d]imidazole-5-carboxylate 943513-37-9 C33H36FN5O5 601.678 —— 1-cyclohexyl-2-[2-fluoro-4-(2-morpholin-4-yl-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester 844891-81-2 C32H33FN4O6 588.636 —— methyl 1-cyclohexyl-2-(2-fluoro-4-((5-nitro-2-(piperidin-1-yl)benzyl)oxy)phenyl)-1H-benzo[d]imidazole-5-carboxylate 943513-34-6 C33H35FN4O5 586.663 —— methyl 1-cyclohexyl-2-(2-fluoro-4-((2-methoxy-5-(2-oxopyrrolidin-1-yl)benzyl)oxy)phenyl)-1H-benzo[d]imidazole-5-carboxylate 943513-53-9 C33H34FN3O5 571.648 —— methyl 1-cyclohexyl-2-(2-fluoro-4-((5-(2-oxopyrrolidin-1-yl)-2-(piperidin-1-yl)benzyl)oxy)phenyl)-1H-benzo[d]imidazole-5-carboxylate 943513-48-2 C37H41FN4O4 624.755 —— 2-{4-[5-(acetyl)(isopropyl)amino-2-morpholin-4-ylbenzyloxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzimidazole-carboxylic acid methyl ester 943513-70-0 C37H43FN4O5 642.771 —— 1-cyclohexyl-2-{2-fluoro-4-[2-[(2-methoxyethyl)methylamino]-5-(2-oxopyrrolidin-1-yl)benzyloxy]phenyl}-1H-benzimidazole-5-carboxylic acid methyl ester 943513-56-2 C36H41FN4O5 628.744 —— methyl 1-cyclohexyl-2-(2-fluoro-4-((2-(4-hydroxypiperidin-1-yl)-5-nitrobenzyl)oxy)phenyl)-1H-benzo[d]imidazole-5-carboxylate 943513-35-7 C33H35FN4O6 602.663 —— 1-cyclohexyl-2-[4-(5-dimethylcarbamoyl-2-morpholin-4-ylbenzyloxy)-2-fluorophenyl]-1H-benzimidazole-5-carboxylic acid methyl ester 943513-71-1 C35H39FN4O5 614.717 —— methyl 2-(4-((2-(4-acetylpiperazin-1-yl)-5-nitrobenzyl)oxy)-2-fluorophenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylate 943513-38-0 C34H36FN5O6 629.688 —— methyl 2-(4-((5-amino-2-(3-oxomorpholino)benzyl)oxy)-2-fluorophenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylate 943513-46-0 C32H33FN4O5 572.636 —— methyl 1-cyclohexyl-2-(2-fluoro-4-((5-(isopropylcarbamoyl)-2-morpholinobenzyl)oxy)phenyl)-1H-benzo[d]imidazole-5-carboxylate 943513-72-2 C36H41FN4O5 628.744 —— 1-cyclohexyl-2-{2-fluoro-4-[morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyloxy]phenyl}-1H-benzimidazole-5-carboxylic acid methyl ester 943513-54-0 C36H39FN4O5 626.728 —— methyl 1-cyclohexyl-2-(2-fluoro-4-((2-(4-methylpiperazin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl)oxy)phenyl)-1H-benzo[d]imidazole-5-carboxylate 943513-51-7 C37H42FN5O4 639.77 —— 1-(2-((4-(1-cyclohexyl-5-(methoxycarbonyl)-1H-benzo[d]imidazol-2-yl)-3-fluorophenoxy)methyl)-4-nitrophenyl)piperidine-4-carboxylic acid 943513-36-8 C34H35FN4O7 630.673 —— 2-{4-[5-(3-chloropropane-1-sulfonylamino)-2-morpholin-4-ylbenzyloxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 943513-59-5 C35H40ClFN4O6S 699.243 —— methyl 1-cyclohexyl-2-(2-fluoro-4-((2-(4-hydroxypiperidin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl)oxy)phenyl)-1H-benzo[d]imidazole-5-carboxylate 943513-49-3 C37H41FN4O5 640.755 —— methyl 1-cyclohexyl-2-(2-fluoro-4-((2-morpholino-5-(2-oxopiperidin-1-yl)benzyl)oxy)phenyl)-1H-benzo[d]imidazole-5-carboxylate 943513-68-6 C37H41FN4O5 640.755 —— methyl 2-(4-((2-(4-acetylpiperazin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl)oxy)-2-fluorophenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylate 943513-52-8 C38H42FN5O5 667.78