bromosulfurous acid ethyl ester | 871877-14-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: bromosulfurous acid ethyl ester
• 英文别名: Bromsulfinsaeure-aethylester；Aethyl-bromsulfinat；Bromoschwefligsaeure-aethylester；Bromosulfinyloxyethane
• CAS: 871877-14-4
• 化学式: C₂H₅BrO₂S
• 分子量: 173.03
• InChiKey: WIMUCJHTWQAZAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  bromosulfurous acid ethyl ester 生成 溴乙烷 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Carre; Libermann, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1933, vol. 197, p. 1327

  摘要：

  DOI：
• 作为产物：
  描述：

  亚硫酸二乙酯 在 二溴亚砜 、 乙醚 作用下， 生成 bromosulfurous acid ethyl ester
  参考文献：
  名称：

  Carre; Libermann, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1933, vol. 197, p. 1327

  摘要：

  DOI：

文献信息

• The Role of Excitotoxic Injury in Post-Traumatic Syringomyelia
  作者：Andrew R. Brodbelt、Marcus A. Stoodley、Amy Watling、Christopher Rogan、Jian Tu、Christopher J. Brown、Seán Burke、Nigel R. Jones

  DOI：10.1089/089771503322385818

  日期：2003.9

  Fifty percent of patients with neurological deterioration from post-traumatic syringomyelia do not respond to treatment. Treatment failure is due in part to an incomplete understanding of the underlying aetiology. An animal model that mimics the human disease is required to investigate underlying pathophysiology and treatment options. A previous study was designed to mimic trauma-induced effects on the spinal cord that result in syringomyelia, combining an excitotoxic insult with kaolin-induced arachnoiditis. In this excitotoxic model, syringes were produced in 82% of animals. The aims of the current study were to improve the model to produce syringes in all animals treated, to examine the relative influences of excitotoxic injury and neuronal loss on syrinx formation, and to use magnetic resonance imaging (MRI) to examine syringes non-invasively. A temporal and dose profile of intraparenchymal quisqualic acid (QA) and subarachnoid kaolin was performed in Sprague Dawley rats. MRI was used to study four syrinx and six control animals. In one subgroup of animals surviving for 6 weeks, 100% (eight of eight) developed syringes. Syrinx formation and enlargement occurred in a dose and time dependent manner, whilst significant neuronal loss was only dose dependent. Animal syrinx histology closely resembled human post-traumatic syringomyelia. Axial T2-weighted MR images demonstrated syrinx presence. The results suggest that the formation of an initial cyst predisposes to syrinx formation in the presence of subarachnoid adhesions.