2-(2,4-difluorophenoxy)pyridine | 1357293-56-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2,4-difluorophenoxy)pyridine
• CAS: 1357293-56-1
• 化学式: C₁₁H₇F₂NO
• 分子量: 207.179
• InChiKey: USCNMHOGXCYBJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-溴苯甲醚 、 2-(2,4-difluorophenoxy)pyridine 在 (p-cymene)ruthenium(II) chloride 、 2,4,6-三甲基苯甲酸 、 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以99%的产率得到2-{(3,5-difluoro-4'-methoxy[1,1'-biphenyl]-2-yl)oxy}pyridine
  参考文献：
  名称：

  Ruthenium-Catalyzed C–H Bond Arylations of Arenes Bearing Removable Directing Groups via Six-Membered Ruthenacycles

  摘要：

  Ruthenium-catalyzed direct arylations of phenols bearing removable directing groups were accomplished through carboxylate assistance via six-membered ruthenacycles as key intermediates.

  DOI：

  10.1021/ol3000876

文献信息

• Indole modulators of ATP-binding cassette transporters
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP2363128A2

  公开（公告）日：2011-09-07

  The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

  本发明涉及 ATP 结合盒（"ABC"）转运体或其片段（包括囊性纤维化跨膜传导调节器（"CFTR"））的调节剂、其组合物以及使用方法。本发明还涉及使用此类调节剂治疗 ABC 转运体介导的疾病的方法。
• (6-(PHENOXY)-PYRIDO[3,4-D]PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS SUCH AS RHEUMATOID ARTHRITIS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1620105A1

  公开（公告）日：2006-02-01
• AMINOQUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES
  申请人：Genentech, Inc.

  公开号：US20170173026A1

  公开（公告）日：2017-06-22

  The invention provides a method of inhibiting angiogenesis in a patient by administering a compound of formula (I): wherein R 1 R 2 and R 3 are as defined herein, compositions including the compounds and methods of using the compounds.
• US9855269B2
  申请人：——

  公开号：US9855269B2

  公开（公告）日：2018-01-02
• [EN] (6-(PHENOXY)-PYRIDO`3,4-D! PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORYY CONDITIONS SUCH AS RHEUMATOIS ARTRITIS<br/>[FR] DERIVES AMINES DE (6-(PHENOXY)-PYRIDO`3,4-D! PYRIMIDIN-2-YLE) EN TANT QU'INHIBITEURS DE LA KINASE P38 POUR LE TRAITEMENT DE CONDITIONS INFLAMMATOIRES TELLES QUE LA POLYARTHRITE RHUMATOIDE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004091625A1

  公开（公告）日：2004-10-28

  The present invention relates to compounds of Formula (I) or (II) , wherein R, R6, R7 and Q are as defined in the specification. The compounds are useful as p38 kinase inhibitors, and therefore, may be used for treatment of p38- mediated disorder.