(2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-(2-(pyridin-2-yldisulfaneyl)ethoxy)tetrahydro-2H-pyran-3,4,5-triol | 1450615-18-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-(2-(pyridin-2-yldisulfaneyl)ethoxy)tetrahydro-2H-pyran-3,4,5-triol
• CAS: 1450615-18-5
• 化学式: C₁₃H₁₉NO₆S₂
• 分子量: 349.429
• InChiKey: VMDNWNJHUUWRNG-WSLQDRLSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.36
• 重原子数：
  22.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  112.27
• 氢给体数：
  4.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  2,2'-二硫二吡啶 、 (2-Thioethyl) α-D-mannopyranoside 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 以76%的产率得到(2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-(2-(pyridin-2-yldisulfaneyl)ethoxy)tetrahydro-2H-pyran-3,4,5-triol
  参考文献：
  名称：

  A monosaccharide-modified peptide phage library for screening of ligands to carbohydrate-binding proteins

  摘要：

  A monosaccharide-modified beta-loop peptide library displayed on phage has been constructed and used for the screening of glycopeptide ligands against a carbohydrate-binding protein. The beta-loop peptide library was designed and modified with a mannose derivative on phage. The glycopeptide ligands to concanavalin A (ConA), a mannose-binding protein, were obtained from the mannose-modified peptide phage library. The amino acids neighboring the mannose unit of glycopeptides not only reinforced the binding affinity but also gave diverse binding characteristics. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.06.059