[EN] INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS<br/>[FR] COMPOSÉS D'INDOLE OU BENZIMIDAZOLE CONVENANT COMME INHIBITEURS DE LA KINASE MTOR
申请人:AMGEN INC
公开号:WO2010096314A1
公开(公告)日:2010-08-26
The present invention provides compounds that are kinase inhibitors, specifically PIK kinase inhibitors, more specifically, mTOR inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PIK kinase inhibitors, more specifically, mTOR such as cancer. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
本发明提供了一种激酶抑制剂化合物,具体来说是PIK激酶抑制剂,更具体地说是mTOR抑制剂,因此适用于治疗通过抑制激酶治疗的疾病,特别是PIK激酶抑制剂,更具体地说是mTOR抑制剂,例如癌症。还提供了含有这些化合物的药物组合物和制备这些化合物的方法。