5-benzyloxy-2-methyl-1-thiazolinoethyl-4(1H)-pyridone | 959676-10-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-benzyloxy-2-methyl-1-thiazolinoethyl-4(1H)-pyridone
• 英文别名: 5-Benzyloxy-1-[2-(4,5-dihydrothiazol-2-yl)ethyl]-2-methyl-pyridin-4-one；1-[2-(4,5-dihydro-1,3-thiazol-2-yl)ethyl]-2-methyl-5-phenylmethoxypyridin-4-one
• CAS: 959676-10-9
• 化学式: C₁₈H₂₀N₂O₂S
• 分子量: 328.435
• InChiKey: HLNQATXNPZAWMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  67.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-benzyloxy-2-methyl-1-thiazolinoethyl-4(1H)-pyridone 在 盐酸 作用下， 反应 24.0h， 以69.2%的产率得到
  参考文献：
  名称：

  Synthesis and antimicrobial investigation of thiazolinoalkyl-4(1H)-pyridones

  摘要：

  A number of thiazolinoalkyl-4(1H)-pyridones have been synthesized using 4-pyrone derivatives with cysteamine HCl, and their antibacterial and antifungal activities have been tested. Their chemical structures have been proved by means of their IR, H-1-NMR, mass spectroscopic data and by elemental analysis. investigation of antimicrobial activity of compounds was done by tube dilution and disk techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus faecalis RSKK 10541) and yeast-like fungi (Candida parapsilosis, C albicans, C pseudotropicalis, C stellatoidea). A significant inhibitory effect was recorded for many compounds against C albicans (7a, c, d; minimal inhibitory concentration (MIC) = 12.5-25 mu g/ml), S aureus ATCC 25923 (4c, 7a; MIC = 25 mu g/ml), P aeruginosa ATCC 27923 (7a; MIC = 25 mu g/ml), S faecalis RSKK 10541 (4c; MIC = 25 mu g/ml), C pseudotropicalis (4d, 6d, 7c; MIC = 25 mu g/ml) and C stellatoidea (4d; MIC = 25 mu g/ml).

  DOI：

  10.1016/0223-5234(94)90113-9
• 作为产物：
  描述：

  5-(benzyloxy)-2-methyl-4H-pyran-4-one 在 吡啶 作用下， 以 乙醇 为溶剂， 反应 22.0h， 生成 5-benzyloxy-2-methyl-1-thiazolinoethyl-4(1H)-pyridone
  参考文献：
  名称：

  Synthesis and antimicrobial investigation of thiazolinoalkyl-4(1H)-pyridones

  摘要：

  A number of thiazolinoalkyl-4(1H)-pyridones have been synthesized using 4-pyrone derivatives with cysteamine HCl, and their antibacterial and antifungal activities have been tested. Their chemical structures have been proved by means of their IR, H-1-NMR, mass spectroscopic data and by elemental analysis. investigation of antimicrobial activity of compounds was done by tube dilution and disk techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus faecalis RSKK 10541) and yeast-like fungi (Candida parapsilosis, C albicans, C pseudotropicalis, C stellatoidea). A significant inhibitory effect was recorded for many compounds against C albicans (7a, c, d; minimal inhibitory concentration (MIC) = 12.5-25 mu g/ml), S aureus ATCC 25923 (4c, 7a; MIC = 25 mu g/ml), P aeruginosa ATCC 27923 (7a; MIC = 25 mu g/ml), S faecalis RSKK 10541 (4c; MIC = 25 mu g/ml), C pseudotropicalis (4d, 6d, 7c; MIC = 25 mu g/ml) and C stellatoidea (4d; MIC = 25 mu g/ml).

  DOI：

  10.1016/0223-5234(94)90113-9

文献信息

• Synthesis and antimicrobial investigation of thiazolinoalkyl-4(1H)-pyridones
  作者：D EROL、N YULUG

  DOI：10.1016/0223-5234(94)90113-9

  日期：——

  A number of thiazolinoalkyl-4(1H)-pyridones have been synthesized using 4-pyrone derivatives with cysteamine HCl, and their antibacterial and antifungal activities have been tested. Their chemical structures have been proved by means of their IR, H-1-NMR, mass spectroscopic data and by elemental analysis. investigation of antimicrobial activity of compounds was done by tube dilution and disk techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus faecalis RSKK 10541) and yeast-like fungi (Candida parapsilosis, C albicans, C pseudotropicalis, C stellatoidea). A significant inhibitory effect was recorded for many compounds against C albicans (7a, c, d; minimal inhibitory concentration (MIC) = 12.5-25 mu g/ml), S aureus ATCC 25923 (4c, 7a; MIC = 25 mu g/ml), P aeruginosa ATCC 27923 (7a; MIC = 25 mu g/ml), S faecalis RSKK 10541 (4c; MIC = 25 mu g/ml), C pseudotropicalis (4d, 6d, 7c; MIC = 25 mu g/ml) and C stellatoidea (4d; MIC = 25 mu g/ml).