Dimethyl 3-methyl-5-[[4-[2-(methylcarbamoyl)pyridin-4-yl]oxyphenyl]methylcarbamoylamino]thiophene-2,4-dicarboxylate | 1025959-74-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Dimethyl 3-methyl-5-[[4-[2-(methylcarbamoyl)pyridin-4-yl]oxyphenyl]methylcarbamoylamino]thiophene-2,4-dicarboxylate
• CAS: 1025959-74-3
• 化学式: C₂₄H₂₄N₄O₇S
• 分子量: 512.543
• InChiKey: PEYPSNVAACEHAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  173
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• METHYLENE UREA DERIVATIVES
  申请人：Buchstaller Hans-Peter

  公开号：US20090298885A1

  公开（公告）日：2009-12-03

  The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• Methylene Urea Derivatives
  申请人：Merck Patent GmbH

  公开号：US20130158076A1

  公开（公告）日：2013-06-20

  The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• US8410143B2
  申请人：——

  公开号：US8410143B2

  公开（公告）日：2013-04-02