[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid | 26893-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
• CAS: 26893-31-2
• 化学式: C₁₁H₇NO₄
• mdl: MFCD24391286
• 分子量: 217.181
• InChiKey: VLGRGWXPFVWTQR-UHFFFAOYSA-N

物化性质

• 沸点：
  424.6±40.0 °C(Predicted)
• 密度：
  1.545±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  68.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] A ONE POT SYNTHESIS OF 3-SUBSTITUTED QUINOLINE CARBOXYLATES AND ITS DERIVATIVES<br/>[FR] SYNTHÈSE MONOTOPE DE QUINOLÉINE CARBOXYLATES SUBSTITUÉS EN POSITION 3 ET DE LEURS DÉRIVÉS
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2015198349A1

  公开（公告）日：2015-12-30

  The present invention provides a one pot, simple, cost effective and industrially feasible catalytic synthesis of quinolines or substituted quinolines from anilines with yield >80% yield. The present invention also discloses a process for the synthesis of oxolinic acid using quinolines with yield > 45%.

  本发明提供了一种一锅法、简单、成本效益高且工业上可行的催化合成喹啉或取代喹啉的方法，产率>80%。本发明还揭示了一种使用喹啉合成噁唑酸的方法，产率>45%。
• Quinoline derivatives and preparation thereof
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US10227355B2

  公开（公告）日：2019-03-12

  The patent discloses novel quinoline derivatives of formula (I), (Formula should be inserted here) and process for preparing the same. The compounds of formula (I) can be further used for the synthesis of Inhibitors like Kinase Tyrosine Inhibitors.

  该专利公开了式 (I) 的新型喹啉衍生物（此处应插入式）及其制备方法。式 (I) 化合物可进一步用于合成激酶酪氨酸抑制剂等抑制剂。
• QUINOLINE-3-CARBOXAMIDES AS H-PGDS INHIBITORS
  申请人：Astex Therapeutics Limited

  公开号：EP3390384B1

  公开（公告）日：2021-09-15
• Uniformly spreadable granular agricultural chemicals formulation and method for scattering (applying) thereof
  申请人：KUMIAI CHEMICAL INDUSTRY CO., LTD.

  公开号：US20040011262A1

  公开（公告）日：2004-01-22

  An object of the present invention is to provide a uniformly spreadable granular agricultural chemical formulation and to establish a method of scattering (applying) the formulation under the assumption that the spreadability of the agrochemically active ingredient is satisfactory so that the expected treatment effect of the agricultural chemicals can be obtained by local application even when algae are drifted by the wind and cover the surface of the water of the paddy field. A uniformly spreadable granular agricultural chemicals formulation which contains an agrochemically active ingredient, has a particle-size distribution such that 80% or more of the granules have a particle diameter of 3 mm or more, and has floatability on the water surface, and breaks down on the water surface within 30 minutes is obtained, and a method of scattering (applying) the above formulation on 5% to 50% of the total area of the paddy field applied from a levee at a distance of 1 m or more.
• NOVEL QUINOLINE DERIVATIVES AND PREPARATION THEREOF
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US20180237448A1

  公开（公告）日：2018-08-23

  The patent discloses novel quinoline derivatives of formula (I), (Formula should be inserted here) and process for preparing the same. The compounds of formula (I) can be further used for the synthesis of Inhibitors like Kinase Tyrosine Inhibitors.