4-氯-8-三氟甲氧基-2-三氟甲基喹啉 | 306935-27-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-氯-8-三氟甲氧基-2-三氟甲基喹啉
• 英文名称: 4-chloro-8-trifluoromethoxy-2-trifluoromethyl quinoline
• 英文别名: 4-Chloro-8-(trifluoromethoxy)-2-(trifluoromethyl)quinoline
• CAS: 306935-27-3
• 化学式: C₁₁H₄ClF₆NO
• 分子量: 315.602
• InChiKey: INCNYMOBGMRZKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  8

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2933499090

文献信息

• Antagonists of melanin concentrating hormone effects on the melanin concetrating hormone receptor
  申请人：——

  公开号：US20030229119A1

  公开（公告）日：2003-12-11

  The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

  本发明涉及通过黑素浓缩激素受体对黑素浓缩激素（MCH）效果的拮抗，对于预防或治疗进食障碍、体重增加、肥胖、生殖和性行为异常、甲状腺激素分泌、利尿和水/电解质平衡、感觉处理、记忆、睡眠、觉醒、焦虑、抑郁、癫痫发作、神经退行性疾病和精神疾病是有用的。
• Thiazolidine derivative and medicinal use thereof
  申请人：——

  公开号：US20040259883A1

  公开（公告）日：2004-12-23

  A thiazolidine derivative represented by the formula (I) 1 wherein each symbol is as defined in the specification, and a pharmaceutically acceptable salt thereof exhibit a potent DPP-IV inhibitory activity, and can be provided as an agent for the prophylaxis or treatment of diabetes, an agent for the prophylaxis or treatment of obesity and the like.

  一种噻唑啉衍生物，其化学式为(I)1，其中每个符号如规范中所定义，其药物可接受的盐具有强效的DPP-IV抑制活性，可作为糖尿病的预防或治疗剂，肥胖症的预防或治疗剂等。
• THIAZOLIDINE DERIVATIVES AND MEDICINAL USE THEREOF
  申请人：SAKASHITA Hiroshi

  公开号：US20070259880A1

  公开（公告）日：2007-11-08

  A thiazolidine derivative represented by the formula (I) wherein each symbol is as defined in the specification, and a pharmaceutically acceptable salt thereof exhibit a potent DPP-IV inhibitory activity, and can be provided as an agent for the prophylaxis or treatment of diabetes, an agent for the prophylaxis or treatment of obesity and the like.

  一种由式(I)所表示的噻唑啉衍生物，其中每个符号如规范中所定义，并且其药物可接受的盐表现出强效的DPP-IV抑制活性，可以作为预防或治疗糖尿病的药剂，预防或治疗肥胖等药剂。
• THIAZOLIDINE DERIVATIVE AND MEDICINAL USE THEREOF
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1426366A1

  公开（公告）日：2004-06-09

  A thiazolidine derivative represented by the formula (I) wherein each symbol is as defined in the specification, and a pharmaceutically acceptable salt thereof exhibit a potent DPP-IV inhibitory activity, and can be provided as an agent for the prophylaxis or treatment of diabetes, an agent for the prophylaxis or treatment of obesity and the like.

  由式（I）表示的噻唑烷衍生物 其中各符号如说明书中所定义，其药学上可接受的盐具有强效的 DPP-IV 抑制活性，可作为预防或治疗糖尿病的制剂、预防或治疗肥胖症的制剂等。
• US6818772B2
  申请人：——

  公开号：US6818772B2

  公开（公告）日：2004-11-16