Linrodostat mesylate | 2221034-29-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Linrodostat mesylate
• 英文别名: (2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide;methanesulfonic acid
• CAS: 2221034-29-1
• 化学式: C25H28ClFN2O4S
• 分子量: 507.0
• InChiKey: LZNFBNWGSDOVIO-WNDXPBGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.08
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US11236048B2

  公开（公告）日：2022-02-01

  The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

  本公开涉及改进的取代喹啉基环己基丙酰胺化合物的制备方法。
• Amorphous and crystalline forms of IDO inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US11236049B2

  公开（公告）日：2022-02-01

  The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.

  本公开涉及无定形和结晶形式的(R)-N-(4-氯苯基)-2-((1S,4S)-4-(6-氟-喹啉-4-基)环己基)丙酰胺及其盐类和水合物、其生产工艺、包含它们的药物组合物以及使用它们的治疗方法。
• SUBSTITUTED QUINOLINYCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION
  申请人：Bristol-Myers Squibb Company

  公开号：EP3645008A1

  公开（公告）日：2020-05-06
• AMORPHOUS AND CRYSTALLINE FORMS OF IDO INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP3644993A1

  公开（公告）日：2020-05-06
• SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20200123109A1

  公开（公告）日：2020-04-23

  The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.