Desoxychinin | 874498-43-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Desoxychinin
• 英文别名: 2-(6-methoxy-quinolin-4-ylmethyl)-5-vinyl-1-aza-bicyclo[2.2.2]octane；6'-methoxy-cinchonane；6'-Methoxy-cinchonan；4-[(5-Ethenyl-1-azabicyclo[2.2.2]octan-2-yl)methyl]-6-methoxyquinoline
• CAS: 874498-43-8
• 化学式: C₂₀H₂₄N₂O
• 分子量: 308.423
• InChiKey: VZRLVENHGDTDDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] SYNTHESIS OF FLUORINATED NUCLEOTIDES<br/>[FR] SYNTHÈSE DE NUCLÉOTIDES FLUORÉS
  申请人：MERCK SHARP & DOHME

  公开号：WO2022035917A1

  公开（公告）日：2022-02-17

  The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O-[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2'-(S)-fluoro-thio-adenosine monophosphate or 2'-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

  本发明涉及有效的过程，用于制备氟代核苷，例如（O-[(2R,3R,4S,5R)-5-(6-氨基-9H-嘌呤-9-基)-4-氟-3-羟基氧杂环己烷-2-基]甲基}O，O-二氢磷酸硫酯，也称为2'-(S)-氟硫腺苷酸单磷酸酯或2'-F-硫-AMP。这种氟代核苷可以用作生物活性化合物，或用作更复杂生物活性化合物的合成中间体。本发明还涵盖了在所披露的合成过程中有用的中间体及其制备方法。
• [EN] CINCHONIUM BETAINE CATALYSTS AND METHODS OF USING SAME<br/>[FR] CATALYSEURS À BASE DE CINCHONIUM BETAÏNE ET MÉTHODES D'UTILISATION
  申请人：UNIV BRANDEIS

  公开号：WO2017181012A1

  公开（公告）日：2017-10-19

  Provided herein are cinchonium betaine catalysts and methods of promoting asymmetric imine isomerization reactions using the same.

  本文提供了肌碱甜菜碱催化剂及其使用方法，用于促进不对称亚胺异构化反应。
• Asymmetric aldol additions using bifunctional cinchona-alkaloid-based catalysts
  申请人：Deng Li

  公开号：US20070112199A1

  公开（公告）日：2007-05-17

  One aspect of the present invention relates to asymmetric catalytic nitroaldol (Henry) reactions with ketones as the electrophilic component. In one embodiment, the present invention relates to asymmetric nitroaldol reactions with α-keto esters catalyzed by a new C6′-OH cinchona alkaloid catalyst. In certain embodiments, this reaction is operationally simple and affords high enantioselectivity as well as good to excellent yield for an exceptionally broad range of α-keto esters.
• [EN] CONJUGATE ADDITION REACTIONS USING BIFUNCTIONAL CINCHONA-ALKALOID-BASED CATALYSTS<br/>[FR] RÉACTIONS D'ADDITION DE CONJUGUÉS UTILISANT DES CATALYSEURS BIFONCTIONNELS À BASE D'ALCALOÏDES DE QUINQUINA
  申请人：UNIV BRANDEIS

  公开号：WO2010077607A2

  公开（公告）日：2010-07-08

  One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene, comprising the step of: reacting a prochiral electron-deficient alkene with a nucleophile in the presence of a catalyst; thereby producing a chiral, non-racemic compound; wherein said catalyst is a derivatized quinine or quinidine.
• [EN] PROCESS FOR THE SYNTHESIS OF SUBSTITUTED TETRAHYDROFURAN MODULATORS OF SODIUM CHANNELS<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE MODULATEURS DE TÉTRAHYDROFURANE SUBSTITUÉS DE CANAUX SODIQUES
  申请人：[en]VERTEX PHARMACEUTICALS INCORPORATED

  公开号：WO2022256660A1

  公开（公告）日：2022-12-08

  Provided in this application is a process for making Compound I (I) and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. Processes for making various intermediate products, and suitable salts thereof, are also provided.