3-((2-(benzo[d]thiazol-2-yl)hydrazineylidene)methyl)quinolin-2-ol | 1226812-82-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-((2-(benzo[d]thiazol-2-yl)hydrazineylidene)methyl)quinolin-2-ol
• CAS: 1226812-82-3
• 化学式: C₁₇H₁₂N₄OS
• 分子量: 320.374
• InChiKey: YUSJGZLQWBCXCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.0
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.4
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  2-肼基苯并噻唑 、 1,2-二氢-2-氧代喹啉-3-甲醛 以 乙醇 为溶剂， 以70%的产率得到3-((2-(benzo[d]thiazol-2-yl)hydrazineylidene)methyl)quinolin-2-ol
  参考文献：
  名称：

  Synthesis, characterization, antibiogram and DNA binding studies of novel Co(II), Ni(II), Cu(II), and Zn(II) complexes of Schiff base ligands with quinoline core

  摘要：

  A series of Co(II), Ni(II), Cu(II), and Zn(II) complexes of Schiff base ligands (LH3)-H-1 and (LH)-H-2 have been prepared. The ligands are synthesized by the condensation of 2-hydroxy-3-formylquinoline with salicyloylhydrazide and 2-hydrazinobenzothiazole in absolute ethanol. The prepared complexes were characterized by the analytical and spectral techniques. The stoichiometry of the complexes is found to be 1:1. The presence of coordinated and lattice water is confirmed by the TG and DTA studies. Subsequently all the prepared complexes were screened for antimicrobial activity against bacteria and fungi. The Cu(II) complexes have been found to be more active than the ligand. In addition the DNA binding/cleaving capacity of the compounds was analyzed by absorption spectroscopy, viscosity measurement, thermal denaturation, and gel electrophoresis methods.

  DOI：

  10.1007/s00044-010-9330-5