8-methyl-1-(2-methylphenyl)-2,3-dihydropyrrolo[2,3-b]quinoline | 140633-28-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-methyl-1-(2-methylphenyl)-2,3-dihydropyrrolo[2,3-b]quinoline
• CAS: 140633-28-9
• 化学式: C₁₉H₁₈N₂
• 分子量: 274.365
• InChiKey: ZHOSQIQLHZYKHP-UHFFFAOYSA-N

物化性质

• 沸点：
  454.6±34.0 °C(Predicted)
• 密度：
  1.174±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.55
• 重原子数：
  21.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  16.13
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2-(2-ethoxyethyl)-N,N'-bis(2-methylphenyl)malonodiamide 在 palladium on activated charcoal 氢气 、 三氯氧磷 作用下， 以 乙醇 、 异丙醇 为溶剂， 150.0 ℃ 、399.99 kPa 条件下， 反应 35.5h， 生成 8-methyl-1-(2-methylphenyl)-2,3-dihydropyrrolo[2,3-b]quinoline
  参考文献：
  名称：

  Reversible inhibitors of the gastric (H+/K+)-ATPase. 2. 1-Arylpyrrolo[3,2-c]quinolines: effect of the 4-substituent

  摘要：

  Further work on compounds 1 has identified the 4-position as a site where substantial modifications are tolerated, leading to analogues which are more potent and less toxic than those described previously. The best compound in the series is 13a (SK&F 96356), which is a potent inhibitor of gastric acid secretion in both the pentagastrin-stimulated rat and the histamine-stimulated dog. This compound shows reversible, K+-competitive binding to the enzyme. Because of its fluorescent properties, it is also proving useful in vitro as a probe of the structure and function of the (H+/K+)-ATPase.

  DOI：

  10.1021/jm00088a021