| 916763-02-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 916763-02-5
• 化学式: C₆₂H₉₅N₃O₁₅
• 分子量: 1122.45
• InChiKey: XMPVOOSQRSPIDN-YSUJMUMMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.26
• 重原子数：
  80.0
• 可旋转键数：
  20.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  196.16
• 氢给体数：
  1.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  在 甲醇 作用下， 反应 6.0h， 以78%的产率得到
  参考文献：
  名称：

  Synthesis and antibacterial activity of 4″-O-heteroarylcarbamoyl derivatives of macrolide

  摘要：

  A series of novel 4 ''-position modified macrolide derivatives has been synthesized via a facile procedure. Their in vitro antibacterial activities against constitutively erythromycin-resistant strains were evaluated. Among the derivatives tested, compound 8a which has 11,12-carbamate and 4 ''-O-heteroarylcarbamoyl groups was found to have potent activity against most resistant bacteria. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.022
• 作为产物：
  描述：

  、 苯基-4-丁胺 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 反应 10.0h， 生成
  参考文献：
  名称：

  Synthesis and antibacterial activity of 4″-O-heteroarylcarbamoyl derivatives of macrolide

  摘要：

  A series of novel 4 ''-position modified macrolide derivatives has been synthesized via a facile procedure. Their in vitro antibacterial activities against constitutively erythromycin-resistant strains were evaluated. Among the derivatives tested, compound 8a which has 11,12-carbamate and 4 ''-O-heteroarylcarbamoyl groups was found to have potent activity against most resistant bacteria. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.022