but-3-yn-1-yl 1H-imidazole-1-carboxylate | 909707-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: but-3-yn-1-yl 1H-imidazole-1-carboxylate
• 英文别名: 3-Butyn-1-yl 1H-imidazole-1-carboxylate；but-3-ynyl imidazole-1-carboxylate
• CAS: 909707-34-2
• 化学式: C₈H₈N₂O₂
• 分子量: 164.164
• InChiKey: DUKATMULQYHZTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  but-3-yn-1-yl 1H-imidazole-1-carboxylate 在 一水合肼 、 三乙胺 、 对甲苯磺酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 19.0h， 生成 methyl 5-(but-3-ynyloxy)-1,3,4-oxadiazole-2-carboxylate
  参考文献：
  名称：

  Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles

  摘要：

  Full details of a systematic exploration of the intramolecular [4+2]/[3+2] cycloaddition cascade of 1,3,4-oxadiazoles are disclosed in which the scope and utility of the reaction are defined.

  DOI：

  10.1021/ja0612549
• 作为产物：
  描述：

  3-丁炔-1-醇 生成 but-3-yn-1-yl 1H-imidazole-1-carboxylate
  参考文献：
  名称：

  SILICON PHTHALOCYANINE AND TRIBENZOPHTHALOCYANINE DYES AND THEIR USE IN DIAGNOSIS AND THERAPY

  摘要：

  本申请涉及新型A3B型硅酞菁，其中包括新的硅三苯酞菁染料。 首先，理解句子内容，明确涉及的是新的硅酞菁及其相关染料类别。 其次，准确翻译各个技术术语，如“A3B型”、“硅酞菁”、“硅三苯酞菁染料”等，确保专业术语的一致性和准确性。 然后，优化语句结构，使句子在中文中更流畅自然，添加适当的连接词和标点符号，比如使用“包括”和逗号来分隔不同部分。 最后，再次审阅翻译结果，确保信息传达准确，句子通顺，符合中文阅读习惯。

  公开号：

  EP4435060A1

文献信息

• SUBSTANCE HAVING AFFINITY FOR ANTIBODY, AND COMPOUND OR SALT THEREOF HAVING BIOORTHOGONAL FUNCTIONAL GROUP
  申请人：AJINOMOTO CO., INC.

  公开号：EP3811978A1

  公开（公告）日：2021-04-28

  The present invention provides a technique enabling modification of an antibody, particularly regioselective modification of an antibody. More specifically, the present invention provides a compound having an affinity substance to an antibody and a bioorthogonal functional group, represented by the following Formula (I):         A-L-E-B     (I) wherein A is an affinity substance to an antibody, L is a divalent group comprising a leaving group, E is a divalent group comprising an electrophilic group (i) coupled with the leaving group and (ii) having ability to react with a nucleophilic group in the antibody, B is a bioorthogonal functional group, and the leaving group has ability to be cleaved and eliminated from E by a reaction between the nucleophilic group and the electrophilic group, or a salt thereof, and the like.

  本发明提供了一种抗体修饰技术，尤其是抗体的区域选择性修饰。更具体地说，本发明提供了一种具有抗体亲和性物质和生物正交官能团的化合物，由下式（I）表示： A-L-E-B (I) 其中 A 是与抗体亲和的物质、 L 是由离去基团组成的二价基团、 E 是二价基团，包括亲电基团，(i) 与离去基团偶联，(ii) 能与抗体中的亲核基团反应、 B 是生物正交官能团，以及 离去基团能够通过亲核基团与亲电基团或其盐类之间的反应从 E 中裂解和消除。
• 含肼屈嗪的高效抗肿瘤纳米载药体系及其制备方法
  申请人：上海浙江大学高等研究院

  公开号：CN115120573A

  公开（公告）日：2022-09-30

  本发明公开了一种含肼屈嗪的高效抗肿瘤纳米载药体系（H‑NPs），所述载药体系是以通过ππ键结合后的肼屈嗪与阿霉素作为疏水核心，以葡聚糖作为亲水外壳。本发明的含肼屈嗪的高效抗肿瘤纳米载药体系可通过扩张肿瘤血管和调节TME，从而增加肿瘤部位的血管通透性、血液灌注、改善纳米颗粒在肿瘤内的富集和渗透、减少肿瘤乏氧，增加肿瘤对化疗药物阿霉素的敏感度，显著提高其抗肿瘤效果。
• [EN] DICTYOSTATIN PRODRUGS AND METHODS OF THEIR USE<br/>[FR] PROMÉDICAMENTS DE DICTYOSTATINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV PENNSYLVANIA

  公开号：WO2015006535A3

  公开（公告）日：2015-04-16
• COMPOUND HAVING AFFINITY SUBSTANCE TO ANTIBODY AND BIOORTHOGONAL FUNCTIONAL GROUP, OR SALT THEREOF
  申请人：Ajinomoto Co., Inc.

  公开号：US20210139541A1

  公开（公告）日：2021-05-13

  Compounds having an affinity substance to an antibody and a bioorthogonal functional group, represented by the following Formula (I): A-L-E-B  (I) wherein A is an affinity substance to an antibody, L is a divalent group comprising a leaving group, E is a divalent group comprising an electrophilic group (i) coupled with the leaving group and (ii) having ability to react with a nucleophilic group in the antibody, B is a bioorthogonal functional group, and the leaving group has ability to be cleaved and eliminated from E by a reaction between the nucleophilic group and the electrophilic group, or a salt thereof, and the like are useful for labelling antibodies.
• Electrolyte for Lithium Secondary Battery and Lithium Secondary Battery Including the Same
  申请人：LG Energy Solution, Ltd.

  公开号：US20220140391A1

  公开（公告）日：2022-05-05

  The present invention relates to an electrolyte for a lithium secondary battery and a lithium secondary battery including the same. In some embodiments, the electrolyte includes a lithium salt, a first additive, a second additive, and an organic solvent, wherein the first additive includes a compound represented by Formula 1 and the second additive includes a compound represented by Formula 2.