5-[2-(1,2,3,6-Tetrahydro-pyridin-4-yl)-4-(2-trifluoromethyl-phenoxymethyl)-benzyloxy]-quinoline | 474330-44-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-[2-(1,2,3,6-Tetrahydro-pyridin-4-yl)-4-(2-trifluoromethyl-phenoxymethyl)-benzyloxy]-quinoline
• 英文别名: 5-[[2-(1,2,3,6-Tetrahydropyridin-4-yl)-4-[[2-(trifluoromethyl)phenoxy]methyl]phenyl]methoxy]quinoline
• CAS: 474330-44-4
• 化学式: C₂₉H₂₅F₃N₂O₂
• 分子量: 490.525
• InChiKey: NGDMBOZDXOZKRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  43.4
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Inhibitors of bace
  申请人：——

  公开号：US20030095958A1

  公开（公告）日：2003-05-22

  The present invention relates to inhibitors of aspartic proteinases, particularly, BACE. The present invention also relates to compositions thereof and methods therewith for inhibiting BACE activity in a mammal, and for treating Alzheimer's Disease and other BACE-mediated diseases.

  本发明涉及天冬氨酸蛋白酶抑制剂，特别是BACE。本发明还涉及其组合物和方法，用于在哺乳动物中抑制BACE活性，并用于治疗阿尔茨海默病和其他BACE介导的疾病。
• INHIBITORS OF BACE
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1389194A2

  公开（公告）日：2004-02-18
• [EN] INHIBITORS OF BACE<br/>[FR] INHIBITEURS DE BACE
  申请人：VERTEX PHARMA

  公开号：WO2002088101A2

  公开（公告）日：2002-11-07

  The present invention relates to inhibitors of aspartic proteinases, particularly, BACE. The present invention also relates to compositions thereof and methods therewith for inhibiting BACE activity in a mammal, and for treating Alzheimer's Disease and other BACE-mediated diseases.