(E)-1-[4-(4-chlorobenzyl)piperazin-1-yl]-3-[3-chloro-5-methyl-4-({5-[2-(4-methylphenyl)-ethoxy]pyridin-2-yl}oxy)phenyl]prop-2-en-1-one | 1322779-20-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-1-[4-(4-chlorobenzyl)piperazin-1-yl]-3-[3-chloro-5-methyl-4-({5-[2-(4-methylphenyl)-ethoxy]pyridin-2-yl}oxy)phenyl]prop-2-en-1-one
• 英文别名: (E)-3-[3-chloro-5-methyl-4-[5-[2-(4-methylphenyl)ethoxy]pyridin-2-yl]oxyphenyl]-1-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]prop-2-en-1-one
• CAS: 1322779-20-3
• 化学式: C₃₅H₃₅Cl₂N₃O₃
• 分子量: 616.587
• InChiKey: JVDBEHLPOYJLSI-NTEUORMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  43
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  54.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Cyclic bent allene metal complexes
  申请人：THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

  公开号：EP2949656A1

  公开（公告）日：2015-12-02

  The present invention provides stable, cyclic bent allene metal complexes and methods of conducting chemical processes, preferably olefin hydrogenation, comprising contacting an olefin substrate, preferably an unsaturated polymer, with a cyclic bent allene metal complex as described herein, under hydrogenation conditions. wherein M is a transition metal selected from Groups 6-11 of the periodic table, L1 is a cyclic bent allene ligand according to the general formula (II)

  本发明提供了稳定的、环状的弯曲联苯金属配合物以及进行化学过程的方法，优选烯烃加氢，包括将烯烃底物，优选不饱和聚合物，与本文所述的环状弯曲联苯金属配合物在加氢条件下接触，其中M是周期表第6-11族中选择的过渡金属，L1是符合通用式(II)的环状弯曲联苯配体。
• DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS
  申请人：Takasu Hideki

  公开号：US20120283242A1

  公开（公告）日：2012-11-08

  The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R 1 and R 2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G 2 -, —N(lower alkyl)-G 2 -, —NH—CH 2 -G 2 -, —N(lower alkyl)-CH 2 -G 2 - or —CH 2 -G 2 -, [wherein G 2 binds to R 2 , G 2 -R 2 is bond-R 2 , phenylene-G 3 -R 2 , phenylene-G 4 -O—R 2 , phenylene-G 5 -NH—R 2 , phenylene-G 6 -N(lower alkyl)-R 2 or quinolinediyl-O—R 2 , the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G 3 -R 2 is —O-lower alkylene-R 2 or the like; G 4 -O— is lower alkylene-O— or the like; G 5 is lower alkylene; G 6 is lower alkylene].

  本发明提供了一种具有优异抗肿瘤效果的新型化合物。本发明的化合物由下述通式（1）表示，其中R1和R2为芳基或类似物；A为低级烷基；环X为可选取代的芳基；E为键或低级烯基；环Y为可选取代的杂环烷基，其中一个氮原子连接到相邻的羰基；G为—NH-G2-，—N(低级烷基)-G2-，—NH—CH2-G2-，—N(低级烷基)- -G2-或— -G2-，[其中G2与R2相连，G2-R2为键-R2，苯基-G3-R2，苯基-G4-O—R2，苯基-G5-NH—R2，苯基-G6-N(低级烷基)-R2或喹啉基-O—R2，所述苯基含有的苯基-含基团可选取代一个或多个取代基；G3-R2为—O-低级烷基-R2或类似物；G4-O—为低级烷基-O—或类似物；G5为低级烷基；G6为低级烷基]。
• RUTHENIUM-BASED COMPLEXES, THEIR PREPARATION AND USE AS CATALYSTS
  申请人：LANXESS DEUTSCHLAND GMBH

  公开号：US20160090396A1

  公开（公告）日：2016-03-31

  The present invention relates to novel Ruthenium-based complex compounds which represent viable catalysts, in particular for all sorts of metathesis reactions. Such complex compounds can be prepared by a novel, very favourable and cost efficient method which includes the introduction of an alkylidene ligand into the complex by using vinyl sulfides or vinyl ethers.

  本发明涉及一种新型基于钌的复合物化合物，它们是可行的催化剂，特别是用于各种交换反应。这种复合物可以通过一种新颖、非常优越和成本效益高的方法制备，该方法包括使用乙烯基硫醚或乙烯基醚将烷基亚烯配体引入到复合物中。
• Process for the preparation of polymers containing amino groups employing a heterogeneous iron catalyst
  申请人：LANXESS Deutschland GmbH

  公开号：EP2918610A1

  公开（公告）日：2015-09-16

  The present invention is related to a process for the preparation of polymers containing amino groups by hydrogenation of nitrile groups containing polymers by heterogeneous catalysis.

  本发明涉及一种通过异相催化使含有腈基的聚合物氢化来制备含有氨基的聚合物的工艺。
• Ruthenium-based triazole carbene complexes
  申请人：The Governing Council of the University of Toronto

  公开号：EP2937357A1

  公开（公告）日：2015-10-28

  Ruthenium-based triazole carbene complexes The present invention relates to novel ruthenium-based triazole carbene complexes comprising specific ligands, their preparation and their use as catalysts in hydrogenation processes. Such complex catalysts are inexpensive, thermally robust, gel formation inhibiting and olefin selective.

  钌基三氮唑碳烯配合物 本发明涉及包含特定配体的新型钌基三氮唑碳烯络合物、其制备及其在氢化过程中作为催化剂的用途。这种络合物催化剂价格低廉、热稳定性好、具有凝胶形成抑制作用和烯烃选择性。