2-(4-bromophenyl)-8-methoxy-4H-chromen-4-one | 1338789-46-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(4-bromophenyl)-8-methoxy-4H-chromen-4-one
• 英文别名: 2-(4-Bromophenyl)-8-methoxychromen-4-one；2-(4-bromophenyl)-8-methoxychromen-4-one
• CAS: 1338789-46-0
• 化学式: C₁₆H₁₁BrO₃
• 分子量: 331.166
• InChiKey: ZQJXIIZHJCRZNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (4-溴苯基)乙炔 、 邻香草醛 在 哌啶 、 iron(III) chloride 作用下， 以 甲苯 为溶剂， 反应 8.0h， 以86%的产率得到2-(4-bromophenyl)-8-methoxy-4H-chromen-4-one
  参考文献：
  名称：

  A novel one pot route to flavones under dual catalysis, an organo- and a Lewis acid catalyst

  摘要：

  Substituted phenylacetylenes react with various o-hydroxy aromatic aldehydes under dual catalysis of piperidine and FeCl3 in refluxing toluene to yield flavones in good to excellent yield. Atmospheric oxygen acts as stoichiometric oxidant in the process. Some of these compounds had been recently reported to show fair insecticidal activity against Spodoptera frugiperda. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.078

文献信息

• A novel one pot route to flavones under dual catalysis, an organo- and a Lewis acid catalyst
  作者：Gourhari Maiti、Rajiv Karmakar、Rudraksha N. Bhattacharya、Utpal Kayal

  DOI：10.1016/j.tetlet.2011.08.078

  日期：2011.10

  Substituted phenylacetylenes react with various o-hydroxy aromatic aldehydes under dual catalysis of piperidine and FeCl3 in refluxing toluene to yield flavones in good to excellent yield. Atmospheric oxygen acts as stoichiometric oxidant in the process. Some of these compounds had been recently reported to show fair insecticidal activity against Spodoptera frugiperda. (C) 2011 Elsevier Ltd. All rights reserved.