N-[(2-aminoquinolin-6-yl)methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide | 1347633-90-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[(2-aminoquinolin-6-yl)methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide
• CAS: 1347633-90-2
• 化学式: C₂₅H₃₂N₄O₅S
• 分子量: 500.619
• InChiKey: RDUOVIITYYQVHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  123
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• NOVEL COMPOUNDS
  申请人：Hauel Norbert

  公开号：US20110294775A1

  公开（公告）日：2011-12-01

  Novel compounds which are useful for treating acute pain, visceral pain, neuropathic pain, inflammatory/pain receptor-mediated pain, tumour pain and headache diseases. The following is exemplary:

  新颖的化合物，可用于治疗急性疼痛、内脏疼痛、神经痛、炎症/疼痛受体介导的疼痛、肿瘤疼痛和头痛疾病。以下是示例：
• ARYLSULFONAMIDE MIT ANALGETISCHER WIRKUNG
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2188251B1

  公开（公告）日：2015-04-29
• Compounds
  申请人：Kauffmann-Hefner Iris

  公开号：US20090137545A1

  公开（公告）日：2009-05-28

  The present invention relates to compounds of general formula I wherein A, B, D, Y, R 1 , R 2 , R 3 , R 4 and R 5 are defined as in the specification, the enantiomers, the diastereomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.
• New Compounds
  申请人：KAUFFMANN-HEFNER Iris

  公开号：US20110021488A1

  公开（公告）日：2011-01-27

  The present invention relates to compounds of general formula I wherein A, B, D, Y, R 1 , R 2 , R 3 , R 4 and R 5 are defined as in the specification, the enantiomers, the diastereomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.
• US7858618B2
  申请人：——

  公开号：US7858618B2

  公开（公告）日：2010-12-28