2-chloro-2-fluoro-1-(4-fluoro-phenyl)-ethanone | 395-32-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-chloro-2-fluoro-1-(4-fluoro-phenyl)-ethanone
• 英文别名: 2-Chlor-2-fluor-1-(4-fluor-phenyl)-aethanon；2-Chloro-2-fluoro-1-(4-fluorophenyl)ethanone
• CAS: 395-32-4
• 化学式: C₈H₅ClF₂O
• 分子量: 190.577
• InChiKey: GNTXCVSJRAUKDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氟-1-(4-氟苯基)-乙酮 在 磺酰氯 作用下， 生成 2-chloro-2-fluoro-1-(4-fluoro-phenyl)-ethanone
  参考文献：
  名称：

  Methyl-fluorinated Methyldiarylcarbinols and Related Compounds

  摘要：

  DOI：

  10.1021/ja01572a051

文献信息

• Azolylmethyloxiranes, Their Use for Controlling Phytopathogenic Fungi, and Compositions Comprising Them
  申请人：Dietz Jochen

  公开号：US20100179058A1

  公开（公告）日：2010-07-15

  The present invention relates to azolylmethyloxiranes of the general formula I in which A is phenyl which is substituted by two F, B is unsubstituted pyridyl, thienyl, thiazolyl, oxazolyl or furyl or is phenyl which is optionally substituted by one to three of the following substituents: halogen, NO 2 , amino, C 1 -C 4 -alkyl, C 1 -C 4 alkoxy, C 1 -C 4 -haloalkyl, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylamino, thio or C 1 -C 4 -alkylthio, with the proviso that B is not o-methylphenyl if A is 2,4-difluorophenyl, and to the plant-compatible acid addition salts or metal salts thereof, to the use of the compounds of the formula I for controlling phytopathogenic fungi and to compositions comprising these compounds.

  本发明涉及一般式I的氮杂环氧环丙烷，其中A为被两个F取代的苯基，B为未取代的吡啶基、噻吩基、噻唑基、噁唑基或呋喃基，或者为苯基，苯基可选择地被以下一到三种取代基之一取代：卤素、NO2、氨基、C1-C4烷基、C1-C4烷氧基、C1-C4卤代烷基、C1-C4卤代烷氧基、C1-C4烷基氨基、硫醚或C1-C4烷基硫醚，但若A为2,4-二氟苯基，则B不为邻甲基苯基，并涉及其与植物相容的酸盐或金属盐，以及将一般式I化合物用于控制植物病原真菌和包含这些化合物的组合物。
• PROCESS FOR PREPARING VORICONAZOLE BY USING NEW INTERMEDIATES
  申请人：Kwon Hyuk Chul

  公开号：US20130005973A1

  公开（公告）日：2013-01-03

  Provided is a process for preparing Voriconazole represented by Chemical Formula 1. More particularly, the process for preparing Voriconazole of Chemical Formula 1 includes: carrying out the Reformatsky-type coupling reaction between a ketone derivative of Chemical Formula 4 and a pyrimidine derivative of Chemical Formula 5 to obtain a compound of Chemical Formula 3; reacting the substituents halo and oxysulfonyl with a hydrogen donor to obtain racemic Voriconazole of Chemical Formula 2; and carrying out optical isolation of the racemic Voriconazole by adding an adequate optically active acid thereto to obtain Voriconazole having high optical purity with high cost-efficiency and high yield.

  提供的是一种制备化学式1所代表的伏立康唑（Voriconazole）的过程。更具体地，制备化学式1的伏立康唑的过程包括：在化学式4的酮衍生物和化学式5的嘧啶衍生物之间进行Reformatsky型偶联反应，以获得化学式3的化合物；将卤素和氧磺酰基的取代基与氢供体反应，以获得化学式2的外消旋伏立康唑；通过向外消旋伏立康唑中添加适量的光学活性酸进行光学隔离，以获得具有高光学纯度、高成本效益和高产率的伏立康唑。
• [EN] INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF EFINACONAZOLE<br/>[FR] COMPOSÉS INTERMÉDIAIRES ET PROCÉDÉ PORU LA PRÉPARATION D'EFINACONAZOLE
  申请人：MAPI PHARMA LTD

  公开号：WO2016079728A1

  公开（公告）日：2016-05-26

  The present invention relates to a process for the preparation of (2R,3R)-2-(2,4- difluorophenyl)-3-(4-methylene-1-piperidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (Efinaconazole) and intermediates used in such process.

  本发明涉及一种用于制备（2R,3R）-2-(2,4-二氟苯基)-3-(4-亚甲基-1-哌啶基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇（依非康唑）及在该过程中使用的中间体的方法。
• DIARYLSULTAM DERIVATIVES
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP0881220A1

  公开（公告）日：1998-12-02

  Compounds represented by the formula: A-C(X)(Y)-C(R1)(R2)-Z, wherein Z represents, for example, a group of -N(R3)-(CH2)p-B wherein R3 is alkyl group or other; p is integer of 3 to 8; B is a group represented by the following formula: wherein R7, R8, R9 and R10 represent hydrogen atom, halogen atom, alkyl group or other; X' is -S-, S(O)-, -S(O)2-, -O-, or -N(R11)- wherein R11 is hydrogen atom, alkyl group or acyl group; W and W' represent benzene ring, or 5- to 7-membered heteroaryl group; X is cycloalkyl group, aryl group or other; Y is hydrogen atom, alkyl group, alkenyl group or other; A is -O-R6 wherein R6 is hydrogen atom, alkyl group, cycloalkyl group etc.; and R1 and R2 represent hydrogen atom, alkyl group or other. The compounds have high affinity and selectivity for sigma 2 binding site, and therefore they are useful as selective sigma 2 ligands for therapeutic and/or preventive treatment of various diseases and symptoms caused by sigma 2 ligands.

  由式表示的化合物：A-C(X)(Y)-C(R1)(R2)-Z，其中 Z 代表例如-N(R3)-(CH2)p-B 的基团，其中 R3 是烷基或其他基团；p 是 3 至 8 的整数；B 是下式所代表的基团： 其中 R7、R8、R9 和 R10 代表氢原子、卤素原子、烷基或其他； X'是-S-、S(O)-、-S(O)2-、-O-或-N(R11)-，其中 R11 是氢原子、烷基或酰基；W 和 W'代表苯环或 5 至 7 元杂芳基；X 代表环烷基、芳基或其他；Y 代表氢原子、烷基、烯基或其他；A 代表-O-R6，其中 R6 代表氢原子、烷基、环烷基等。R1 和 R2 代表氢原子、烷基或其他。 这些化合物对 sigma 2 结合位点具有高亲和力和选择性，因此可作为选择性 sigma 2 配体，用于治疗和/或预防由 sigma 2 配体引起的各种疾病和症状。
• AZOLE COMPOUNDS AS THERAPEUTIC AGENTS FOR FUNGAL INFECTIONS
  申请人：Ranbaxy Laboratories, Limited

  公开号：EP1278755A2

  公开（公告）日：2003-01-29