(E)-3-(5-bromo-4-methylpent-3-enyl)tetrahydrofuran | 1331771-22-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 英文名称: (E)-3-(5-bromo-4-methylpent-3-enyl)tetrahydrofuran
• CAS: 1331771-22-2
• 化学式: C₁₀H₁₇BrO
• 分子量: 233.148
• InChiKey: KPNNXJIAQAXNGL-YCRREMRBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.14
• 重原子数：
  12.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (E)-3-(5-bromo-4-methylpent-3-enyl)tetrahydrofuran 、 (E,E)-farnesyl phenylsulfone 在 potassium tert-butylate 、 氯化铵 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 以66%的产率得到3-((3E,7E,11E)-4,8,12,16-tetramethyl-6-(phenylsulfonyl)heptadeca-3,7,11,15-tetraen-1-yl)tetrahydrofuran
  参考文献：
  名称：

  Concise synthesis and structure–activity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge

  摘要：

  Structure activity relationship of furospinosulin-1 (1), a hypoxia-selective growth inhibitor isolated from marine sponge, was investigated. Concise synthetic method of 1 was developed, and some structurally modified analogues were prepared. Biological evaluation of them revealed that the whole chemical structure was important for the hypoxia-selective growth inhibitory activity of 1. Among prepared, the desmethyl analogue 30 showed excellent hypoxia-selective inhibitory activity similar to that of 1 and also exhibited in vivo anti-tumor activity with oral administration. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.05.009
• 作为产物：
  描述：

  3-(四氢呋喃-3-基)丙酸乙酯 在 四溴化碳 、 二异丁基氢化铝 、 三苯基膦 、 pyridinium chlorochromate 作用下， 以 正己烷 、 二氯甲烷 、 甲苯 为溶剂， 反应 17.83h， 生成 (E)-3-(5-bromo-4-methylpent-3-enyl)tetrahydrofuran
  参考文献：
  名称：

  Concise synthesis and structure–activity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge

  摘要：

  Structure activity relationship of furospinosulin-1 (1), a hypoxia-selective growth inhibitor isolated from marine sponge, was investigated. Concise synthetic method of 1 was developed, and some structurally modified analogues were prepared. Biological evaluation of them revealed that the whole chemical structure was important for the hypoxia-selective growth inhibitory activity of 1. Among prepared, the desmethyl analogue 30 showed excellent hypoxia-selective inhibitory activity similar to that of 1 and also exhibited in vivo anti-tumor activity with oral administration. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.05.009