[2-(2-碘乙基)-1,3-二氧戊环-4-基]甲醇 | 104-08-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 中文名称: [2-(2-碘乙基)-1,3-二氧戊环-4-基]甲醇
• 中文别名: 2-(2-碘乙基)-1,3-二氧-4-甲醇
• 英文名称: 2-(2-Iodoethyl)-1,3-dioxolane-4-methanol
• 英文别名: [2-(2-iodoethyl)-1,3-dioxolan-4-yl]methanol
• CAS: 104-08-5
• 化学式: C₆H₁₁IO₃
• 分子量: 258.05
• InChiKey: YPSNTKGTKXXRGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• Apparatus And Methods For Delivering A Plurality Of Medicaments For Management Of Co-Morbid Diseases, Illnesses Or Conditions
  申请人：MILLER Frederick H.

  公开号：US20100221321A1

  公开（公告）日：2010-09-02

  A method and apparatus for delivering a plurality of medicaments in a single delivery vehicle for the management of co-morbid diseases, illnesses and conditions. The present invention provides a novel delivery process for many medicaments. Medicaments may be encapsulated and stored separately within a larger capsule until the time of ingestion, consumption, or the like. Benefits of the present invention include maintaining separation of distinct ingredients within a single capsule and the capability to control the time release of multiple ingredients within the capsule.

  一种用于管理共病疾病、疾病和病状的多种药物在单一输送装置中输送的方法和装置。本发明提供了一种新颖的多种药物输送过程。药物可以被封装并分别存储在更大的胶囊中，直到摄入、消耗或类似的时间。本发明的好处包括在单个胶囊中保持不同成分的分离以及控制胶囊中多种成分的时间释放的能力。
• 4-HYDROXYTHIOBENZAMIDE DERIVATIVES OF DRUGS
  申请人：Wallace John L.

  公开号：US20090306412A1

  公开（公告）日：2009-12-10

  Derivatives of drugs are provided, said derivatives comprising the H2S-releasing moiety 4-hydroxythiobenzamide that is either covalently linked to the drug or forms a salt with the drug. The compounds of the present invention exhibit enhanced activity or reduced side effects or both.

  提供药物的衍生物，所述衍生物包括与药物共价结合或形成盐的释放H2S的基团4-羟基硫代苯甲酰胺。本发明的化合物表现出增强的活性或减少的副作用或两者兼备。
• Pharmaceutical compounds
  申请人：Soldato Del Piero

  公开号：US20050261242A1

  公开（公告）日：2005-11-24

  Compounds or their salts having general formula: A-B—C—NO 2 wherein: A is a drug radical; B is a linker; and C is a bivalent radical.

  化合物或其盐的一般式为：A-B-C-NO2，其中：A是药物基团；B是连接剂；C是双价基团。
• Treatment of colds and cough with a combination of a cyclooxygenase-2 selective inhibitor and a colds and cough active ingredient and compositions thereof
  申请人：Pharmacia Corporation

  公开号：US20040029864A1

  公开（公告）日：2004-02-12

  A method for the treatment, prevention and amelioration of colds and/or cough in a subject in need of such treatment, prevention and amelioration, comprises administering to the subject a cyclooxygenase-2 selective inhibitor or prodrug thereof and one or more colds and cough active ingredient. Compositions, pharmaceutical compositions and kits for practicing the method are also disclosed.

  本发明涉及一种用于治疗、预防和改善感冒和/或咳嗽的方法，包括向需要此类治疗、预防和改善的受试者施用环氧合酶-2选择性抑制剂或其前药以及一个或多个感冒和咳嗽活性成分。还公开了实施该方法的组合物、制药组合物和工具包。