壬醛丙二醇缩醛 | 68391-39-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 中文名称: 壬醛丙二醇缩醛
• 英文名称: 4-methyl-2-octyl-1,3-dioxolane
• 英文别名: nonanal propyleneglycol acetal；nonanal propylene glycol acetal
• CAS: 68391-39-9
• 化学式: C₁₂H₂₄O₂
• 分子量: 200.321
• InChiKey: AGNUIQKIUPCFET-UHFFFAOYSA-N

物化性质

• 沸点：
  242.5±8.0 °C(Predicted)
• 密度：
  0.880±0.06 g/cm3(Predicted)
• LogP：
  3.98
• 物理描述：
  Clear, colourless liquid; Fruity aroma
• 溶解度：
  Insoluble in water; soluble in organic solvents
• 折光率：
  1.430-1.436

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  壬醛 、 1,2-丙二醇 在 对甲苯磺酸 、 calcium chloride 作用下， 反应 1.5h， 以98.73%的产率得到壬醛丙二醇缩醛
  参考文献：
  名称：

  低级醛（C2-C10）丙二醇缩醛的合成方法

  摘要：

  本发明公开了一种低级醛（C 2 -C 10 ）醛丙二醇缩醛的合成方法，本发明的方法通过使用用低级醛（C 2 -C 10 ）、1,2-丙二醇、无水氯化钙、对甲苯磺酸反应来制备目标产物。采用本发明的方法，反应无副产物、无污染、产物纯度高、产品回收率高、成本低、效率高、香气好。经简单搅拌反应缩醛含量可达到大于98%的缩合，适用于调配多种高档香精，对增加香精成品稳定性和耐温性有相当效果。

  公开号：

  CN103554078B

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• Highly effective tandem hydroformylation–acetalization of olefins using a long-life Brønsted acid–Rh bifunctional catalyst in ionic liquid–alcohol systems
  作者：Xin Jin、Kun Zhao、Feifei Cui、Fangfang Kong、Qiangqiang Liu

  DOI：10.1039/c3gc41231h

  日期：——

  A robust and highly effective tandem hydroformylation–acetalization of olefins using a Brønsted acid–Rh bifunctional catalyst (ARBC) in ionic liquid–alcohol systems is reported. The key feature of the ARBC is its use of a zwitterionic phosphine ligand bearing an amino acid tag. This novel ARBC shows an excellent catalytic efficiency and a long service life without a significant drop in both the hydroformylation efficiency and the acetalization efficiency or Rh loss for more than seventeen cycles. We believe that the long-term high activity and acetal selectivity mainly benefit from the synergy between the acidic active site and the Rh active site on the ARBC and the highly effective immobilization and recycling of ARBC in ionic liquid–alcohol systems due to the strong affinity of ARBC for the ionic liquid.

  报道了一种在离子液体-醇体系中使用布朗斯台德酸-铑双功能催化剂(ARBC)对烯烃进行高效且稳定的串联氢甲酰化-缩醛化反应。ARBC的关键特点是其采用了带有氨基酸标记的二性磷配体。这种新型ARBC表现出卓越的催化效率和长寿命，在超过十七个循环后，氢甲酰化效率、缩醛化效率以及铑损失均未出现显著下降。我们认为，长期高活性和缩醛选择性主要得益于ARBC上酸活性位点与铑活性位点之间的协同作用，以及由于ARBC对离子液体的高亲和性，实现了在离子液体-醇体系中高效固定化和循环利用。
• Phosphonium-based aminophosphines as bifunctional ligands for sequential catalysis of one-pot hydroformylation–acetalization of olefins
  作者：Peng Wang、Huan Liu、Yong-Qi Li、Xiao-Li Zhao、Yong Lu、Ye Liu

  DOI：10.1039/c5cy01827g

  日期：——

  involved bifunctional moieties of the phosphine fragment and Lewis acidic phosphonium were linked together by stable chemical bonds and bridged by one N-atom. The molecular structure of the L2-ligated Rh-complex (Rh-L2) indicated that such bifunctionalities were well retained without incompatibility problems. Investigations on co-catalysis over L1–L3 showed that L3 exhibited the best sequential catalysis

  制备并充分表征了一系列基于离子phospho的氨基膦L1 - L3，其中每个膦片段的双功能部分和路易斯酸性phospho通过稳定的化学键连接在一起，并通过一个N原子桥接。与L 2连接的Rh-络合物（Rh-L 2）的分子结构表明，这样的双官能团被很好地保留而没有不相容性问题。在L1 - L3上进行共催化的研究表明，L3在加氢甲酰化和乙缩醛化方面均表现出最佳的顺序催化。L3中的膦片段与Rh配合物一起负责加氢甲酰化反应，而as则充当路易斯酸催化剂，负责乙缩醛化反应。该L3 -Rh（ACAC）（CO）2系统也显示出良好的通用大范围在不同的醇的烯烃的加氢甲酰化，缩醛化。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Polycarbonate resin composition
  申请人：MITSUBISHI ENGINEERING-PLASTICS CORPORATION

  公开号：EP0753540A2

  公开（公告）日：1997-01-15

  A polycarbonate resin composition according to the present invention is suited to be used for medical supplies or appliances and shows a very low yellow discoloration when exposed to an ionizing radiation for sterilization. The polycarbonate resin composition comprises 100 parts by weight of a polycarbonate resin; 0.01 to 5 parts by weight of an aromatic compound containing oxy group or carbonyl group; and 0.01 to 5 parts by weight of at least one compound selected from the group consisting of: (A) a compound containing cyclic acetal group; (B) a sulfone compound; (C) a sulfoxide compound; (D) polyalkylene glycol, an ether of polyalkylene glycol or an ester of polyalkylene glycol; (E) a compound containing sulfonate group; and (F) an aromatic hydrocarbon-aldehyde resin.

  根据本发明的一种聚碳酸酯树脂组合物适合用于医疗用品或器具，在暴露于电离辐射灭菌时，黄色褪色程度很低。聚碳酸酯树脂组合物包括 100 重量份的聚碳酸酯树脂；0.01 至 5 重量份的含氧基或羰基的芳香族化合物；以及 0.(A) 含环缩醛基团的化合物；(B) 砜化合物；(C) 亚砜化合物；(D) 聚亚烷基二醇、聚亚烷基二醇的醚或聚亚烷基二醇的酯；(E) 含磺酸基团的化合物；(F) 芳香烃-醛树脂。

表征谱图