| 714977-86-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 714977-86-3
• 化学式: C₃₆H₆₂N₄O₂₆
• 分子量: 966.899
• InChiKey: JREXSPOMXSGZPZ-ZMQIOPFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -12.55
• 重原子数：
  66.0
• 可旋转键数：
  17.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  479.61
• 氢给体数：
  18.0
• 氢受体数：
  27.0

反应信息

• 作为反应物：
  描述：

  (S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid 、 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Tight binding ligand approach to oligosaccharide-grafted protein

  摘要：

  A novel type of artificial glycoprotein was developed, by using dihydrofolate reductase (DHFR) and methotrexate (MTX) as a protein-ligand pair. Various oligosaccharides linked to MTX were shown to bind tightly with DHFR and afforded oligosaccharide-grafted protein, which could be isolated easily by lectin beads. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.106
• 作为产物：
  描述：

  在 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Tight binding ligand approach to oligosaccharide-grafted protein

  摘要：

  A novel type of artificial glycoprotein was developed, by using dihydrofolate reductase (DHFR) and methotrexate (MTX) as a protein-ligand pair. Various oligosaccharides linked to MTX were shown to bind tightly with DHFR and afforded oligosaccharide-grafted protein, which could be isolated easily by lectin beads. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.106