5-氨基吲哚盐酸盐 | 65795-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 5-氨基吲哚盐酸盐
• 英文名称: N-cyano-N'-(1H-indol-5-yl)guanidine
• 英文别名: 5-aminoindole hydrochloride；1H-indol-5-amine;hydrochloride
• CAS: 65795-92-8
• 化学式: C₈H₈N₂*ClH
• 分子量: 168.626
• InChiKey: CZRIFWIECZRIKN-UHFFFAOYSA-N

物化性质

• 熔点：
  255-257 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  2.17
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.8
• 氢给体数：
  3
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S22,S36/37/39,S45,S7
• 危险类别码：
  R20/21/22,R40
• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  5-氨基吲哚盐酸盐 在 三氟化硼乙醚 、 sodium hydride 作用下， 以 乙二醇二甲醚 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 12.0h， 生成 (1,3-diamino-7H-pyrrolo[3,2-f]quinazolin-7-yl)ethanone
  参考文献：
  名称：

  [EN] PYRROLOQUINAZOLINE COMPOUNDS
  [FR] COMPOSÉS DE PYRROLOQUINAZOLINE

  摘要：

  本文披露了7H-吡咯并[3,2-f]喹唑啉-1,3-二胺的酰化衍生物以及包含这些衍生物的药物组合物。

  公开号：

  WO2014205272A1
• 作为产物：
  描述：

  5-氨基吲哚 在 盐酸 作用下， 以 甲醇 、 乙醚 为溶剂， 生成 5-氨基吲哚盐酸盐
  参考文献：
  名称：

  [EN] PYRROLOQUINAZOLINE COMPOUNDS
  [FR] COMPOSÉS DE PYRROLOQUINAZOLINE

  摘要：

  本文披露了7H-吡咯并[3,2-f]喹唑啉-1,3-二胺的酰化衍生物以及包含这些衍生物的药物组合物。

  公开号：

  WO2014205272A1

文献信息

• Heterocyclic compounds
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0542497A1

  公开（公告）日：1993-05-19

  Compounds of the formula (II): or acid addition salts thereof, wherein R¹ is hydrogen, C₁₋₆ alkyl or C₁₋₄ alkyl substituted by halo or C₁₋₄ alkoxy, R² is C₁₋₄ alkyl or C₁₋₄ alkyl substituted b halo or C₁₋₄ alkoxy, R³ is C₁₋₄ alkyl or C₁₋₄ alkyl substituted by halo or C₁₋₄ alkoxy or forms a C₅₋₇ cycloalkyl or cycloalkenyl group and R⁴ is hydrogen or C₁₋₄ alkyl are described as useful medicaments in the treatment of cancer. Pharmaceutical compositions containing the compounds and their manufacture are also disclosed.

  该公式（II）的化合物或其酸盐，其中R¹为氢、C₁₋₆烷基或通过卤素或C₁₋₄烷氧基取代的C₁₋₄烷基；R²为C₁₋₄烷基或通过卤素或C₁₋₄烷氧基取代的C₁₋₄烷基；R³为C₁₋₄烷基或通过卤素或C₁₋₄烷氧基取代的C₁₋₄烷基，或形成C₅₋₇环烷基或环烯基；R⁴为氢或C₁₋₄烷基。这些化合物被描述为治疗癌症的有用药物。还公开了含有这些化合物的药物组合物及其制备方法。
• Method for producing tryptamine derivatives
  申请人：——

  公开号：US20030096379A1

  公开（公告）日：2003-05-22

  The invention relates to a coupled enzymatic process for producing tryptamine derivatives from indole compounds. In the first enzyme-catalyzed reaction, indole derivatives are converted to tryptophan derivative intermediates, then the tryptophan intermediates are decarboxylated in a second enzymatic reaction in the same reaction system. In this way, tryptamine derivative products are formed from indole derivatives in a single process. The invention is also directed to novel tryptophan and tryptamine derivatives, which can be prepared by the inventive method.

  本发明涉及一种从吲哚化合物中生产色胺衍生物的耦合酶促反应过程。在第一次酶催化反应中，吲哚衍生物被转化为色氨酸衍生物中间体，然后在同一反应体系中进行第二次酶催化反应，将色氨酸中间体脱羧。这样，通过单一过程从吲哚衍生物中形成色胺衍生物产品。该发明还涉及新型色氨酸和色胺衍生物，可以通过本发明方法制备。
• PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES
  申请人：Bednarek Pawel

  公开号：US20090028796A1

  公开（公告）日：2009-01-29

  The present invention is directed to pesticidal compositions comprising indole derivatives. These indole derivatives are especially active against phytopathogenic fungi. Furthermore, the invention relates to the use of indole derivatives for the production of pesticides and the use of the compositions according to the invention as pesticides. The present invention is also directed to a process for producing a pesticidal composition and to pesticidal compositions prepared by this process. In addition, the invention relates to a process for preventing or combating pests and to a process for protecting plants against pests, especially against phytopathogenic fungi. Further, the invention is directed to plants or seeds as well as objects or materials which have been protected against pests by treatment with a composition according to the invention. Further, the invention is directed to a method for identifying a substance having pesticidal activity. Further, the invention is directed to a method of identifying the mode of action of and/or of providing binding proteins for a pesticidal compound of the present invention. Finally, the invention is directed to a method for diagnosing pest infection of a plant and to the use of a pesticidal compound of the present invention as diagnostic markers.

  本发明涉及包含吲哚衍生物的杀虫组合物。这些吲哚衍生物特别对植物病原真菌具有活性。此外，本发明涉及使用吲哚衍生物制备杀虫剂以及使用本发明中的组合物作为杀虫剂。本发明还涉及制备杀虫组合物的过程以及通过该过程制备的杀虫组合物。此外，本发明还涉及预防或对抗害虫的过程以及保护植物免受害虫，特别是植物病原真菌的过程。此外，本发明还涉及经过本发明中的组合物处理后受到保护的植物或种子以及物体或材料。本发明还涉及识别具有杀虫活性的物质的方法。此外，本发明还涉及识别本发明中杀虫化合物的作用方式和/或提供结合蛋白的方法。最后，本发明涉及诊断植物害虫感染的方法以及使用本发明中的杀虫化合物作为诊断标记的方法。
• ARYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS
  申请人：Diaz-Fernandez Jose-Luis

  公开号：US20100120886A1

  公开（公告）日：2010-05-13

  The present invention relates to aryl-substituted sulfonamides with 5-HT 6 receptor affinity, and compositions thereof, and the use of said compounds for the treatment or prophylaxis of various disorders.

  本发明涉及具有5-HT6受体亲和力的芳基取代磺酰胺及其组合物，以及利用该化合物治疗或预防各种疾病的用途。
• COMPOSITIONS FOR DYEING HORNY FIBERS
  申请人：Lion Corporation

  公开号：EP1234569A1

  公开（公告）日：2002-08-28

  A composition for dyeing keratinous fiber which includes incorporated therein an oxidative color-developing substance, an enzyme which reacts with oxygen as a substrate but does not evolve hydrogen peroxide, and a weak reducing agent.

  一种用于角质纤维染色的组合物，其中包括一种氧化显色物质、一种作为底物与氧气反应但不产生过氧化氢的酶和一种弱还原剂。