ethyl 4-(2,6-dimethylquinolin-4-ylamino)benzoate | 74459-59-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 4-(2,6-dimethylquinolin-4-ylamino)benzoate
• 英文别名: 4-(2,6-dimethyl-quinolin-4-ylamino)-benzoic acid ethyl ester；Ethyl 4-[(2,6-dimethylquinolin-4-yl)amino]benzoate
• CAS: 74459-59-9
• 化学式: C₂₀H₂₀N₂O₂
• 分子量: 320.391
• InChiKey: AEWQOWIZGWLFIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 4-(2,6-dimethylquinolin-4-ylamino)benzoate dihydrochloride 在 alkali 作用下， 以 水 为溶剂， 以93%的产率得到ethyl 4-(2,6-dimethylquinolin-4-ylamino)benzoate
  参考文献：
  名称：

  Synthesis and transformations of 2- and 4-(2-Methylquinolin-4-ylamino)benzoic acids and ethyl 4-(2-methylquinolin-4-ylamino)benzoates and their fluorescent properties

  摘要：

  2- and 4-(2-Methylquinolin-4-ylamino)benzoic acids and ethyl 4-(2-methylquinolin-4-ylamino)-benzoates having a substituent in the 6(8)-position of the quinoline ring were synthesized by reaction of the corresponding substituted 4-chloro-2-methylquinolines with 2- and 4-aminobenzoic acids and ethyl 4-aminobenzoate. Intramolecular cyclization of 2-(2-methylquinolin-4-ylamino)benzoic acids in concentrated sulfuric acid gave 7-hydroxy-6-methyldibenzo[b,h][1,6]naphthyridines, and ethyl 4-(2-methylquinolin-4-ylamino)benzoates were converted into 4-(2-methylquinolin-4-ylamino)benzoic acids by alkaline hydrolysis.

  DOI：

  10.1134/s1070428007070196

文献信息

• THAKORE P. V.; TRIVEDI K. N., J. INDIAN CHEM. SOC., 1979, 56, NO 12, 1239-1242
  作者：THAKORE P. V.、 TRIVEDI K. N.

  DOI：——

  日期：——