1-(pyridin-2-yl)-1H-phenalen-9-ol | 1239577-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 1-(pyridin-2-yl)-1H-phenalen-9-ol
• CAS: 1239577-55-9
• 化学式: C₁₈H₁₃NO
• 分子量: 259.307
• InChiKey: JBJFNYPNZXPJAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  33.12
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  1-(pyridin-2-yl)-1H-phenalen-9-ol 在 air 作用下， 以 氯仿 为溶剂， 以18%的产率得到9-(2-pyridyl)-1H-phenalen-1-one
  参考文献：
  名称：

  Synthesis and in vitro antiprotozoal evaluation of substituted phenalenone analogues

  摘要：

  A set of derivatives encompassing structural modifications on the privileged phenalenone scaffold were assessed for their antiparasitic activities against the most clinically relevant forms of trypanosomiasis and leishmaniasis. Several compounds exhibited leishmanicidal effects at levels comparable or better than the reference drug pentamidine, while the parent phenalenone was shown to have a level of activity against Trypanosoma cruzi comparable to the marketed drug benznidazole. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.04.062
• 作为产物：
  描述：

  2-碘吡啶 、 萘嵌苯酮 在 乙基溴化镁 作用下， 以 四氢呋喃 为溶剂， 反应 3.75h， 生成 1-(pyridin-2-yl)-1H-phenalen-9-ol
  参考文献：
  名称：

  Synthesis and in vitro antiprotozoal evaluation of substituted phenalenone analogues

  摘要：

  A set of derivatives encompassing structural modifications on the privileged phenalenone scaffold were assessed for their antiparasitic activities against the most clinically relevant forms of trypanosomiasis and leishmaniasis. Several compounds exhibited leishmanicidal effects at levels comparable or better than the reference drug pentamidine, while the parent phenalenone was shown to have a level of activity against Trypanosoma cruzi comparable to the marketed drug benznidazole. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.04.062