N-(1,3-Diphenyl-2-propyl)-hydroxylamin | 19293-68-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: N-(1,3-Diphenyl-2-propyl)-hydroxylamin
• 英文别名: N-(1,3-diphenylpropan-2-yl)hydroxylamine
• CAS: 19293-68-6
• 化学式: C₁₅H₁₇NO
• mdl: MFCD25259670
• 分子量: 227.306
• InChiKey: UXDHTFQFCLOKDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1,3-Diphenyl-2-propyl)-hydroxylamin 、 N-(氯甲酰)异氰酸酯 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2α inhibitors

  摘要：

  1,2,4-Oxadiazolidiin-3,5-dione and 1,3,5-triazin-2,4,6-trione scaffolds were employed as templates to incorporate the pharmacophore requirements of cytosolic phospholipase A(2)alpha Substrate mimetics. Inhibitors that are active in both enzyme, and cell-based assays were identified from both classes. From the SAR work carried out and modeling efforts around these templates, the triazinetrione scaffold with an additional substitution point was found to be more favorable. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.067
• 作为产物：
  描述：

  二苄醚 在 盐酸 、 吡啶硼烷 作用下， 以 甲醇 为溶剂， 生成 N-(1,3-Diphenyl-2-propyl)-hydroxylamin
  参考文献：
  名称：

  1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2α inhibitors

  摘要：

  1,2,4-Oxadiazolidiin-3,5-dione and 1,3,5-triazin-2,4,6-trione scaffolds were employed as templates to incorporate the pharmacophore requirements of cytosolic phospholipase A(2)alpha Substrate mimetics. Inhibitors that are active in both enzyme, and cell-based assays were identified from both classes. From the SAR work carried out and modeling efforts around these templates, the triazinetrione scaffold with an additional substitution point was found to be more favorable. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.067

文献信息

• Reduction of oximes, oxime ethers, and oxime esters with diborane. Novel synthesis of amines
  作者：Henry Feuer、D. M. Braunstein

  DOI：10.1021/jo01258a062

  日期：1969.6
• 1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2α inhibitors
  作者：Ariamala Gopalsamy、Hui Yang、John W. Ellingboe、John C. McKew、Steve Tam、Diane Joseph-McCarthy、Wen Zhang、Marina Shen、James D. Clark

  DOI：10.1016/j.bmcl.2006.02.067

  日期：2006.6

  1,2,4-Oxadiazolidiin-3,5-dione and 1,3,5-triazin-2,4,6-trione scaffolds were employed as templates to incorporate the pharmacophore requirements of cytosolic phospholipase A(2)alpha Substrate mimetics. Inhibitors that are active in both enzyme, and cell-based assays were identified from both classes. From the SAR work carried out and modeling efforts around these templates, the triazinetrione scaffold with an additional substitution point was found to be more favorable. (c) 2006 Elsevier Ltd. All rights reserved.