3-Methyl-5-methylthio-4-phenyl-4H-1,2,4-triazole | 40279-27-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-Methyl-5-methylthio-4-phenyl-4H-1,2,4-triazole
• 英文别名: 3-Methyl-5-methylthio-4-phenyl-1,2,4-triazol；3-methyl-5-methylsulfanyl-4-phenyl-4H-[1,2,4]triazole；3-Methyl-5-methylmercapto-4-phenyl-4H-[1,2,4]triazol；4H-1,2,4-Triazole, 3-methyl-5-(methylthio)-4-phenyl-；3-methyl-5-methylsulfanyl-4-phenyl-1,2,4-triazole
• CAS: 40279-27-4
• 化学式: C₁₀H₁₁N₃S
• mdl: MFCD02588000
• 分子量: 205.283
• InChiKey: CWDAPYZTJUQYAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  56
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 3-Methyl-5-methylthio-4-phenyl-4H-1,2,4-triazole 、 碘甲烷 在 乙醇 作用下， 反应 4.0h， 以to provide 1,5-dimethyl-3-methylthio-4-phenyl-1,2,4-triazolium iodide的产率得到1,5-Dimethyl-4-phenyl-3-methylmercapto-1,2,4-triazolium-iodid
  参考文献：
  名称：

  Silver halide photographic material

  摘要：

  一种含有中间离子型1,2,4-三唑-3-硫酸盐化合物的银卤化物感光材料，至少在银卤化物感光材料的一个亲水胶体层中，能够形成稳定且质量优异的摄影图像，而不伴随着高温处理时雾化增加和感度及阶调变化增加。

  公开号：

  US04675276A1
• 作为产物：
  描述：

  1-乙酰氨基-3-苯基硫脲 在 sodium ethanolate 作用下， 生成 3-Methyl-5-methylthio-4-phenyl-4H-1,2,4-triazole
  参考文献：
  名称：

  765.哒嗪季盐的结构和反应性

  摘要：

  DOI：

  10.1039/jr9590003789

文献信息

• Non-nucleoside reverse transcriptase inhibitors
  申请人：Girardet Jean-Luc

  公开号：US20060135556A1

  公开（公告）日：2006-06-22

  Various carbonyl amides are employed in vitro and in vivo as non-nucleoside inhibitors of a reverse transcriptase, and particularly of HIV reverse transcriptase. Therefore, contemplated compounds may be employed in the treatment of HIV infected patients. Further contemplated aspects include pharmaceutical compositions comprising therapeutically effective amounts of contemplated compounds.

  各种羰基酰胺在体外和体内被用作非核苷类逆转录酶抑制剂，特别是HIV逆转录酶的抑制剂。因此，考虑到的化合物可用于治疗HIV感染的患者。进一步考虑的方面包括含有考虑到的化合物的治疗有效量的药物组合物。
• Diffusion transfer color photographic material with meso-ionic
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04582775A1

  公开（公告）日：1986-04-15

  A color diffusion transfer photographic light-sensitive material comprising a support, at least one silver halide layer on the support, said emulsion layer being associated with a dye-providing compound, and an image-receiving layer on the same support as above or on another support, wherein said photographic light-sensitive material is able to provide a transferred dye image composed of a diffusible dye or its precursor released or derived from the dye-providing compound as a result of development under a strong alkaline condition in the presence of at least one meso ionic 1,2,4-triazolium-3-thiolate compound. In the present material, fog can be prevented efficiently without causing the problems of a reduction in sensitivity and a decrease in rate of development.

  一种彩色扩散转移照相光敏材料，包括支撑体，在支撑体上至少有一层银卤化物层，该乳剂层与染料提供化合物相关联，并在与上述相同的支撑体或另一支撑体上具有图像接收层，其中该照相光敏材料能够在至少一种中性离子1,2,4-三唑-3-硫酸盐化合物的存在下，在强碱性条件下进行显影，释放或衍生自染料提供化合物的可扩散染料或其前体，形成转移染料图像。在该材料中，可以有效地防止雾化，而不会导致感光度降低和显影速率降低的问题。
• NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
  申请人：Girardet Jean-Luc

  公开号：US20080249131A1

  公开（公告）日：2008-10-09

  Various carbonyl amides are employed in vitro and in vivo as non-nucleoside inhibitors of a reverse transcriptase, and particularly of HIV reverse transcriptase. Therefore, contemplated compounds may be employed in the treatment of HIV infected patients. Further contemplated aspects include pharmaceutical compositions comprising therapeutically effective amounts of contemplated compounds.

  各种羰基酰胺在体外和体内被用作反转录酶的非核苷类抑制剂，尤其是HIV反转录酶的抑制剂。因此，考虑到的化合物可以用于治疗HIV感染患者。进一步考虑的方面包括包含考虑化合物的治疗有效量的制药组合物。
• Compounds Useful In Therapy
  申请人：Bryans Justin Stephen

  公开号：US20100317652A1

  公开（公告）日：2010-12-16

  The present invention provides compounds of formula (I), or pharmaceutically acceptable derivatives thereof wherein the variables Z, Q, Ring A, V, X, Y and Y′ are as defined herein, and pharmaceutical compositions comprising these compounds. The compounds of formula (I) and pharmaceutical compositions comprising them are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.

  本发明提供了式(I)的化合物或其药学上可接受的衍生物，其中变量Z，Q，环A，V，X，Y和Y'如此定义，并且包含这些化合物的药物组合物。式(I)的化合物和包含它们的药物组合物可用于治疗需要V1a拮抗剂的紊乱，特别是痛经。
• The Synthesis of Polyazaindenes and Related Compounds
  作者：G. A. REYNOLDS、J. A. VanALLAN

  DOI：10.1021/jo01092a023

  日期：1959.10