3--phloropropiophenon | 54673-06-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3--phloropropiophenon
• 英文别名: 3-(3-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one；3-(3-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
• CAS: 54673-06-2
• 化学式: C₁₅H₁₄O₅
• 分子量: 274.273
• InChiKey: PVMAAGGMFPPXNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  间-香豆酸 、 丙二酰辅酶A-钠盐 在 Saccharomyces cerevisiae strain AH₂₂ (MATA leu2-3 leu2-112 his4-519 can1) (ATCC 38626) 、 4-coumaroyl:CoA-ligase 、 chalcone synthase 作用下， 反应 72.0h， 生成 4-hydroxy-6-(3-hydroxyphenethyl)-2H-pyran-2-one 、 3--phloropropiophenon
  参考文献：
  名称：

  Synthesis of non-natural flavanones and dihydrochalcones in metabolically engineered yeast

  摘要：

  Flavonoids are plant phenolic compounds that have many interesting medicinal properties. Therefore, there is interest in the synthesis of non-natural flavonoids as they may possess new or enhanced biological activities. In this study, metabolically engineered Saccharomyces cerevisiae expressing 4-coumaroyl:CoA-ligase (4CL) and chalcone synthase (CHS) was explored as a platform for producing non-natural flavanones and dihydrochalcones. By precursor addition of cinnamic acid analogues to the engineered yeast, numerous non-natural flavanones and dihydrochalcones were formed in vivo. Also, several CHS derailment products were formed. Of the isolated compounds, one flavanone and three derailment products were found to be novel compounds. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcatb.2010.05.017

文献信息

• Hair cosmetic composition
  申请人：KAO CORPORATION

  公开号：US10959925B2

  公开（公告）日：2021-03-30

  The hair cosmetic composition of the present invention, which is a one-agent type or a multi-agent type hair cosmetic composition, contains, the following components (A) to (D), the component (C) content, relative to the total composition of the hair cosmetic composition, being 0.1 mass % or higher and lower than 20 mass %: (A): a compound selected from the group consisting of glyoxylic acid, a glyoxylic acid hydrate, a glyoxylate salt, and a glyoxylamide; (B): a phenolic compound having an electron-donating group on at least one m-position and having a hydrogen atom on at least one of the o-positions and the p-position, wherein the electron-donating group on the m-position may form, together with an adjacent carbon atom, a benzene ring optionally substituted with hydroxyl group(s); (C): an organic solvent having a boiling point of 100° C. or higher; and (D): water.

  本发明的头发化妆品组合物是一种单药剂型或多药剂型头发化妆品组合物，含有以下成分（A）至（D），其中成分（C）的含量相对于头发化妆品组合物的总成分而言，大于或等于 0.1 质量%，小于 20 质量%： (A): 选自乙醛酸、乙醛酸水合物、乙醛酸盐和乙醛酰胺组成的化合物； (B) 一种酚类化合物，其至少一个 m 位上有一个电子供体，至少一个 o 位和 p 位上有一个氢原子，其中 m 位上的电子供体可与相邻的碳原子一起形成一个任选被羟基取代的苯环； (C) 沸点为 100 摄氏度或更高的有机溶剂；以及 (D) 水。
• METHOD FOR TREATING HAIR
  申请人：Kao Corporation

  公开号：EP3463264A1

  公开（公告）日：2019-04-10
• HAIR COSMETIC COMPOSITION
  申请人：Kao Corporation

  公开号：EP3463265A1

  公开（公告）日：2019-04-10
• [EN] METHOD FOR TREATING HAIR<br/>[FR] PROCÉDÉ DE TRAITEMENT DES CHEVEUX
  申请人：KAO CORP

  公开号：WO2017207768A1

  公开（公告）日：2017-12-07

  The hair treatment method includes the following steps (i) to (iii) for dyeing hair and at the same time deforming hair semi- permanently or permanently: (i) a step of dyeing hair through a hair treatment including applying a dye to the hair, (ii) a step of applying the following components (A), (B), and (C) to the hair, (A): one or more compounds selected from the group consisting of glyoxylic acid, a glyoxylic acid hydrate, a glyoxylate salt, and a glyoxylamide; (B): a phenolic compound having an electron-donating group on at least one m-position and having a hydrogen atom on at least one of the o-positions and the p-position, wherein the electron- donating group on the m-position may form, together with an adjacent carbon atom, a benzene ring optionally substituted with hydroxyl group(s); (C): water, and (iii) a step of heating and shaping the hair.
• [EN] HAIR COSMETIC COMPOSITION<br/>[FR] COMPOSITION COSMÉTIQUE CAPILLAIRE
  申请人：KAO CORP

  公开号：WO2017207786A1

  公开（公告）日：2017-12-07

  The hair cosmetic composition of the present invention, which is a one-agent type or a multi-agent type hair cosmetic composition, contains, the following components (A) to (D), the component (C) content, relative to the total composition of the hair cosmetic composition, being 0.1 mass% or higher and lower than 20 mass%: (A): a compound selected from the group consisting of glyoxylic acid, a glyoxylic acid hydrate, a glyoxylate salt, and a glyoxylamide; (B): a phenolic compound having an electron-donating group on at least one m-position and having a hydrogen atom on at least one of the o-positions and the p-position, wherein the electron- donating group on the m-position may form, together with an adjacent carbon atom, a benzene ring optionally substituted with hydroxyl group(s); (C): an organic solvent having a boiling point of 100C or higher; and (D): water.