2-Methyl-2-isopropyl-5-hydroxy-6,7-dichlor-1-indanon | 54197-00-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-Methyl-2-isopropyl-5-hydroxy-6,7-dichlor-1-indanon
• 英文别名: 6,7-dichloro-2,3-dihydro-5-hydroxy-2-methyl-2-(1-methylethyl)-1H-inden-1-one；2-Methyl-2-isopropyl-5-hydroxy-6,7-dichloro-1-indanone；6,7-dichloro-5-hydroxy-2-methyl-2-propan-2-yl-3H-inden-1-one
• CAS: 54197-00-1
• 化学式: C₁₃H₁₄Cl₂O₂
• 分子量: 273.159
• InChiKey: OPFJCVOMXOISKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Methyl-2-isopropyl-5-hydroxy-6,7-dichlor-1-indanon 以67%的产率得到
  参考文献：
  名称：

  WOLTERSDORF O. W. JR.; SOLMS S. J. DE; SCHULTZ E. M.; CRAGOE E. J. JR., J. MED. CHEM. , 1977, 20, NO 11, 1400-1408

  摘要：

  DOI：
• 作为产物：
  描述：

  异戊酰氯 在 三氯化铝 溶剂黄146 、 paraformaldehyde 作用下， 以 乙二醇二甲醚 、 正庚烷 、 二氯甲烷 、 硫酸 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 生成 2-Methyl-2-isopropyl-5-hydroxy-6,7-dichlor-1-indanon
  参考文献：
  名称：

  [1-Hydroxy-5-indanyloxy (or thio)]-alkanoic acids

  摘要：

  揭示了1-羟基-5-茚氧（或硫）烷酸及其盐、酯和酰胺。这些产品在药用上具有双重作用，表现出利尿、排钠和降尿酸活性。这些酸产品可以通过几种合成方法制备。

  公开号：

  US04012524A1

文献信息

• [1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic acids
  申请人：Merck & Co., Inc.

  公开号：US03974212A1

  公开（公告）日：1976-08-10

  [1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a 1-oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids or derivatives thereof with hydroxylamine in the presence of a base.

  1-羟基亚胺基-2,2-二取代-5-茚氧基（或硫代）烷酸及其盐、酯、酐、酰胺和5-四唑基衍生物已被披露。这些产品具有双重药用功能，因为它们表现出利尿、排盐和尿酸排泄活性。酸性产物是通过将1-氧代-2,2-二取代-5-茚氧（或硫代）烷酸或其衍生物与羟胺在碱的存在下处理而制备的。
• 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids
  申请人：Merck & Co., Inc.

  公开号：US03984465A1

  公开（公告）日：1976-10-05

  1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a 2,2-disubstituted-5-hydroxy(or mercapto)-1-indanone with an haloalkanoic acid or ester thereof and, if the ester is employed, hydrolyzing the ester.

  披露了1-氧代-2,2-二取代-5-茚氧基（或硫代）脂肪酸及其盐、酯、酸酐、酰胺和5-四唑基衍生物。该产品具有双重药用功能，表现出利尿、盐利和尿酸排泄活性。通过将2,2-二取代-5-羟基（或巯基）-1-茚酮与卤代脂肪酸或其酯进行处理，并在使用酯时水解酯来制备酸产品。
• 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkano acids
  申请人：Merck & Co., Inc.

  公开号：US04081554A1

  公开（公告）日：1978-03-28

  1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a 2,2-disubstituted-5-hydroxy(or mercapto)-1-indanone with an haloalkanoic acid or ester thereof and, if the ester is employed, hydrolyzing the ester.

  本发明揭示了1-氧代-2,2-二取代-5-吲哚氧（或硫）代烷酸及其盐、酯、酐、酰胺和5-四唑基衍生物。这些产物具有双重药用价值，因为它们表现出利尿、排盐和尿酸排泄活性。酸类产物是通过将2,2-二取代-5-羟基（或巯基）-1-吲哚酮与卤代烷酸或其酯进行处理，并且如果使用酯，则水解酯来制备的。
• Substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-Hydroxy-1H-Pyrrole-2,5-diones, their analogs and their salts
  申请人：Merck & Co., Inc.

  公开号：EP0160891A1

  公开（公告）日：1985-11-13

  The invention relates to novel compounds of the formula: in which R and R' are different entities and wherein A is a bond, -0- or -0-(CH2)q; q is 1 to 5; z is 0 or H and OH; R is cycloalkyl, cycloalkyl-lower alkyl, aryl selected from phenyl, halophenyl, methoxyphenyl, hydroxyphenyl, heterocyclic including thienyl, aralkyl selected from benzyl and phenethyl, lower alkyl, lower alkenyl or lower alkynyl; R' is lower alkyl, lower alkenyl; or lower alkynyl; and X and Y are selected from halo and methyl provided that when A is a bond or when A is -O- and z is H and OH, R is not cycloalkyl or alkyl when R' is lower alkyl and both X and Y are chloro when the compounds are racemic. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke, arrested breathing, cardiac arrest, Reye's syndrom, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

  本发明涉及式如下的新型化合物： 其中 R 和 R' 为不同的实体，且 A 是键、-0- 或 -0-(CH2)q q 是 1 至 5 z 是 0 或 H 和 OH； R 是环烷基、环烷基-低级烷基、选自苯基、卤代苯基、甲氧基苯基、羟基苯基的芳基、包括噻吩基在内的杂环基、选自苄基和苯乙基的芳烷基、低级烷基、低级烯基或低级炔基； R' 是低级烷基、低级烯基或低级炔基； X和Y选自卤代和甲基，条件是当A为键或当A为-O-且z为H和OH时，R不是环烷基或当R'为低级烷基时，R不是烷基，且当化合物为外消旋体时，X和Y均为氯代。 这些化合物可用于治疗和预防头部创伤、中风、呼吸停止、心脏骤停、雷氏综合征、脑血栓、脑栓塞、脑出血、脑肿瘤、脑脊髓炎、脊髓损伤、脑积水、脑外伤术后创伤、脑部感染引起的水肿以及各种脑震荡引起的脑部损伤和水肿。
• US3974212A
  申请人：——

  公开号：US3974212A

  公开（公告）日：1976-08-10