3-cyclopentyl-2-quinolin-6-yl-N-(1,3-thiazol-2-yl)propanamide | 928218-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-cyclopentyl-2-quinolin-6-yl-N-(1,3-thiazol-2-yl)propanamide
• CAS: 928218-06-8
• 化学式: C₂₀H₂₁N₃OS
• 分子量: 351.472
• InChiKey: CAXLMOLSYZITDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• THIAZOLE DERIVATIVE
  申请人：Hayakawa Masahiko

  公开号：US20090281142A1

  公开（公告）日：2009-11-12

  [Problem] To provide a compound which is useful as a GK activator. [Means for Resolution] As a result of an extensive study on thiazole derivatives, the present inventors have found that a compound having an oxamoyl group, a glycol group or the like on a thiazole ring and a compound having an acetamide group substituted by a bicyclic heteroaryl group such as a quinolyl have a good GK activation effect, and thereby have accomplished the present invention. Since the compounds of the present invention have a good GK activation effect, these are useful as therapeutic agents for diabetes, particularly type II diabetes.

  [问题] 提供一种作为GK激活剂有用的化合物。[解决方法] 通过对噻唑衍生物的广泛研究，本发明人发现，在噻唑环上具有氧羰基基团、乙二醇基团或类似基团的化合物，以及在乙酰胺基团上被双环杂环基团（如喹啉基团）取代的化合物具有良好的GK激活效果，从而完成了本发明。由于本发明的化合物具有良好的GK激活效果，因此可用作糖尿病治疗剂，特别是II型糖尿病。