7-氯代硫犬尿酸盐酸盐 | 135025-56-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 7-氯代硫犬尿酸盐酸盐
• 英文名称: 7-Chlorothiokynurenic acid
• 英文别名: 7-chloro-4-thio-quinoline-2-carboxylic acid；7-chloro-4-sulfanylidene-1H-quinoline-2-carboxylic acid
• CAS: 135025-56-8
• 化学式: C₁₀H₆ClNO₂S
• 分子量: 239.682
• InChiKey: KSCOHHUVHWAXLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COMBINATIONS OF NMDAR MODULATING COMPOUNDS
  申请人：NORTHWESTERN UNIVERSITY

  公开号：US20170072005A1

  公开（公告）日：2017-03-16

  This disclosure features combinations of NMDAR modulating compounds. This disclosure features combinations that include one or more NMDAR antagonists and GLYX-13 (each of which is sometimes referred to herein as a ‘component”). The beneficial effects of the combination are based, in part, on the finding that administration of GLYX-13 (e.g., a single dose) can reverse and/or prevent NMDAR antagonist-induced cognitive impairment (e.g., NMDAR antagonist-induced impairment in novel object recognition; e.g., induced through repeated dosing of the NMDAR antagonist).
• US5250541A
  申请人：——

  公开号：US5250541A

  公开（公告）日：1993-10-05
• [EN] KYNURENIC ACID DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：FIDIA S.P.A.

  公开号：WO1991001973A1

  公开（公告）日：1991-02-21

  (EN) The compounds of formula (I) (R, R1, R2, R3 and R4 as defined in the specification) are useful as therapeutic agents for the treatment of pathologies of the Central Nervous System.(FR) Composés représentés par la formule (I) (où R, R1, R2, R3 et R4 sont définis dans la description), et qui sont utiles comme agents thérapeutiques dans le traitement des pathologies du système nerveux central.
• [EN] COMPOSITIONS OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS AND NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF NEUROPATHIC PAIN<br/>[FR] COMPOSITIONS D'INHIBITEURS SELECTIFS DE LA CYCLOOXYGENASE-2 ET D'ANTAGONISTES DU RECEPTEUR NMDA DESTINEES AU TRAITEMENT OU A LA PREVENTION DE DOULEURS NEUROPATHIQUES
  申请人：PHARMACIA CORP

  公开号：WO2004039371A2

  公开（公告）日：2004-05-13

  The present invention provides compositions and methods to treat or prevent neuropathic pain in a subject using a combination of a COX-2 selective inhibitor and a NMDA receptor antagonist.