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4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-trifluoromethylphenyl]-4-hydroxytetrahydropyran | 133739-88-5

中文名称
——
中文别名
——
英文名称
4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-trifluoromethylphenyl]-4-hydroxytetrahydropyran
英文别名
6-[[3-(4-hydroxyoxan-4-yl)-5-(trifluoromethyl)phenoxy]methyl]-1-methylquinolin-2-one
4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-trifluoromethylphenyl]-4-hydroxytetrahydropyran化学式
CAS
133739-88-5
化学式
C23H22F3NO4
mdl
——
分子量
433.427
InChiKey
OLKSUKUJTQUDRA-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.2
  • 重原子数:
    31
  • 可旋转键数:
    4
  • 环数:
    4.0
  • sp3杂化的碳原子比例:
    0.35
  • 拓扑面积:
    59
  • 氢给体数:
    1
  • 氢受体数:
    7

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-trifluoromethylphenyl]-4-hydroxytetrahydropyran 以90%的产率得到4-hydroxy-4-(3-hydroxy-5-trifluoromethylphenyl)tetrahydropyran
    参考文献:
    名称:
    Heterocycles for use as inhibitors of leukotrienes
    摘要:
    该发明涉及式I的杂环##STR1##其中Q是一个可选择地取代的含有一个或两个氮原子的6元单环或10元双环杂环基团;A是(1-6C)烷基、(3-6C)烯基、(3-6C)炔基或环(3-6C)烷基;X是氧、硫、亚砜基、磺酰基或亚胺基;Ar是苯基,可以选择性地带有一个或两个取代基,或Ar是一个可选择地取代的含有最多三个氮原子的6元杂环基团;R.sup.1是氢、(1-6C)烷基、(3-6C)烯基、(3-6C)炔基、氰基-(1-4C)烷基或(2-4C)烷酰基,或可选择地取代的苯甲酰基;而R.sup.2和R.sup.3一起形成一个式--A.sup.2--X.sup.2--A.sup.3--的基团,与A.sup.2和A.sup.3连接的碳原子一起定义具有4到7个环原子的环,其中A.sup.2和A.sup.3,可以相同也可以不同,每个是(1-4C)烷基,而X.sup.2是氧、硫、亚砜基、磺酰基或亚胺基;或其药学上可接受的盐。该发明的化合物是5-脂氧合酶的抑制剂。
    公开号:
    US05134148A1
点击查看最新优质反应信息

文献信息

  • Isoquinoline derivatives suitable for use in leukotriene mediated disease
    申请人:Zeneca Limited
    公开号:US05401751A1
    公开(公告)日:1995-03-28
    The invention concerns a heterocycle of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms; R.sup.1 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and R.sup.2 and R.sup.3 together form a group of the formula --A.sup.2 --X.sup.2 --A.sup.3 -- which, together with the carbon atom to which A.sup.2 and A.sup.3 are attached, defines a ring having 4 to 7 ring atoms, wherein A.sup.2 and A.sup.3, which may be the same or different, each is (1-4C)alkylene and X.sup.2 is oxy, thio, sulphinyl, sulphonyl or imino; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.
    该发明涉及公式I的杂环化合物:##STR1## 其中,Q是含有一个或两个氮原子的可选取代的6元单环或10元二环杂环基;A是(1-6C)烷基,(3-6C)烯基,(3-6C)炔基或cyclo(3-6C)烷基;X是氧,,亚磺酰基,磺酰基或亚胺基;Ar是苯基,可以选择带有一个或两个取代基,或者Ar是可选取代的含有最多三个氮原子的6元杂环基;R.sup.1是氢,(1-6C)烷基,(3-6C)烯基,(3-6C)炔基,基-(1-4C)烷基或(2-4C)烷酰基,或者是可选取代的苯甲酰基;R.sup.2和R.sup.3共同形成一个式子--A.sup.2 --X.sup.2 --A.sup.3 --的基团,与A.sup.2和A.sup.3连接的碳原子一起定义具有4至7个环原子的环,其中A.sup.2和A.sup.3,可以相同也可以不同,每个都是(1-4C)烷基,X.sup.2是氧,,亚磺酰基,磺酰基或亚胺基;或其药学上可接受的盐。该发明的化合物是5-脂氧合酶酶的抑制剂
  • Quinoxalinyl derivatives suitable for use in leukotriene mediated disease
    申请人:Imperial Chemical Industries PLC
    公开号:US05236919A1
    公开(公告)日:1993-08-17
    The invention concerns a heterocycle of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms; R.sup.1 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and R.sup.2 and R.sup.3 together form a group of the formula --A.sup.2 --X.sup.2 --A.sup.3 -- which, together with the carbon atom to which A.sup.2 and A.sup.3 are attached, defines a ring having 4 to 7 ring atoms, wherein A.sup.2 and A.sup.3, which may be the same or different, each is (1-4C)alkylene and X.sup.2 is oxy, thio, sulphinyl, sulphonyl or imino; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.
    本发明涉及一种公式I的杂环化合物:##STR1## 其中,Q是一个含有一个或两个氮原子的可选取代的6元单环或10元双环杂环基团;A是(1-6C)烷基,(3-6C)烯基,(3-6C)炔基或环(3-6C)烷基;X是氧,,亚砜,磺酰或亚胺基;Ar是苯基,它可以可选地带有一个或两个取代基,或Ar是一个含有最多三个氮原子的可选取代的6元杂环基团;R1是氢,(1-6C)烷基,(3-6C)烯基,(3-6C)炔基,基-(1-4C)烷基或(2-4C)酰基,或可选取代的苯甲酰基;R2和R3一起形成一个公式--A2--X2--A3--的基团,它与A2和A3所连接的碳原子一起定义了一个具有4到7个环原子的环,其中A2和A3,可以相同也可以不同,每个都是(1-4C)烷基,X2是氧,,亚砜,磺酰或亚胺基;或其药学上可接受的盐。本发明的化合物是5-脂氧酶酶的抑制剂
  • Heterocycles with inhibitory activity of 5-lipoxygenase
    申请人:ZENECA LIMITED
    公开号:EP0385662A2
    公开(公告)日:1990-09-05
    The invention concerns a heterocycle of the formula I wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms; R¹ is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and R² and R³ together form a group of the formula -A²-X²-A³- which, together with the carbon atom to which A² and A³ are attached, defines a ring having 4 to 7 ring atoms, wherein A² and A³, which may be the same or different, each is (1-4C)alkylene and X² is oxy, thio, sulphinyl, sulphonyl or imino; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.
    本发明涉及式 I 的杂环 其中 Q 是含有一个或两个氮原子的任选取代的 6 元单环或 10 元双环杂环分子; A是(1-6C)亚烷基、(3-6C)烯基、(3-6C)炔基或环(3-6C)亚烷基; X 是氧基、代、亚砜基、磺酰基或亚基; Ar 是亚苯基,可任选带有一个或两个取代基,或者 Ar 是任选被取代的含有最多三个氮原子的 6 元杂环分子; R¹是氢、(1-6C)烷基、(3-6C)烯基、(3-6C)炔基、基-(1-4C)烷基或(2-4C)烷酰基,或任选取代的苯甲酰基; 与 R² 和 R³ 一起形成式 -A²-X²-A³- 的基团,该基团与 A² 和 A³ 所连接的碳原子一起定义了一个具有 4 至 7 个环原子的环,其中 A² 和 A³ 可以相同或不同,各自为 (1-4C)烷基,X² 为氧基、基、亚砜基、磺酰基或亚基; 或其药学上可接受的盐。 本发明的化合物是 5-脂氧合酶的抑制剂
  • US5134148A
    申请人:——
    公开号:US5134148A
    公开(公告)日:1992-07-28
  • US5236919A
    申请人:——
    公开号:US5236919A
    公开(公告)日:1993-08-17
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