1,2-bis-β-D-glucopyranosyloxy-ethane | 84852-66-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2-bis-β-D-glucopyranosyloxy-ethane
• 英文别名: 1,2-Bis-β-D-glucopyranosyloxy-aethan；(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]oxane-3,4,5-triol
• CAS: 84852-66-4
• 化学式: C₁₄H₂₆O₁₂
• 分子量: 386.353
• InChiKey: QNVOQXDXUDSEPW-LOUZWEESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  199
• 氢给体数：
  8
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  2,3,4,6-四乙酰氧基-alpha-D-吡喃葡萄糖溴化物 在 甲醇 、 氯仿 、 sodium methylate 、 silver carbonate 、 calcium chloride 作用下， 生成 1,2-bis-β-D-glucopyranosyloxy-ethane
  参考文献：
  名称：

  Helferich; Hiltmann, Justus Liebigs Annalen der Chemie, 1937, vol. 531, p. 160,171, 175

  摘要：

  DOI：

文献信息

• METHODS OF TREATING OCULAR DISORDERS
  申请人：Beta Therapeutics Pty. Ltd.

  公开号：EP3554505A1

  公开（公告）日：2019-10-23
• Methods of Treating Ocular Disorders
  申请人：NELMS Keats

  公开号：US20200093852A1

  公开（公告）日：2020-03-26

  This invention relates to the use of a heparanase inhibitor for treating, or inhibiting the progression or development of, an ocular inflammatory disorder, such as age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, retinal 5 vein occlusion, retinoblastoma, uveitis, macular edema, dry eye, ocular inflammation associated with an infection or keratoconus.
• [EN] BRIDGED OLIGOSACCHARIDES AND SULFATED DERIVATIVES THEREOF<br/>[FR] OLIGOSACCHARIDES PONTES ET LEURS DERIVES SULFATES
  申请人：——

  公开号：WO1995005182A1

  公开（公告）日：1995-02-23

  [EN] The present invention relates to bridged oligosaccharide(s) compounds and sulfated derivatives thereof having the structure R<1>-[X<1>-R<2>]n-X<2>-R<3> wherein R<1>, R<2> and R<3> are independently one or more saccharide(s); X<1> and X<2> are independently difunctional or polyfunctional alkyl, aryl or aralkyl compounds capable of covalently joining together said saccharides; and n is an integer of zero to ten.
  [FR] La présent invention concerne des composés oligosaccharide(s) pontés et ceux de leurs dérivés dont la structure est R<1>-[X<1>-R<2>]n-X<2>-R<3>. Dans cette structure, R<1>, R<2> et R<3> correspondent chacun pour ce qui le concerne à un ou plusieurs saccharide(s), X<1> et X<2> sont des composés alkyle, aryle ou aralkyle difonctionnels ou polyfonctionnels capables de joindre par covalence lesdits saccharides, "n" est un entier valant de zéro à dix.
• [EN] METHODS OF TREATING OCULAR DISORDERS<br/>[FR] MÉTHODES DE TRAITEMENT DE TROUBLES OCULAIRES
  申请人：BETA THERAPEUTICS PTY LTD

  公开号：WO2018107226A1

  公开（公告）日：2018-06-21

  This invention relates to the use of a heparanase inhibitor for treating, or inhibiting the progression or development of, an ocular inflammatory disorder, such as age- related macular degeneration, diabetic retinopathy, retinitis pigmentosa, retinal 5 vein occlusion, retinoblastoma, uveitis, macular edema, dry eye, ocular inflammation associated with an infection or keratoconus.