(S)-3-methoxydecan-1-ol | 1421454-87-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-3-methoxydecan-1-ol
• 英文别名: (3S)-3-methoxydecan-1-ol
• CAS: 1421454-87-6
• 化学式: C₁₁H₂₄O₂
• 分子量: 188.31
• InChiKey: FVSDHZHOJJXJTA-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-3-methoxydecan-1-ol 在 lithium hexamethyldisilazane 、 2-碘酰基苯甲酸 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 1.5h， 生成 (S,E)-2-(7-methoxytetradec-4-enyloxy)-tetrahydro-2H-pyran
  参考文献：
  名称：

  Novel malyngamide structural analogs: synthesis and biological evaluation

  摘要：

  In the course of our search for new anticancer agents, a series of novel malyngamide derivatives were synthesized by sharpless asymmetric epoxidation, followed by Julia-Kocinski olefination reactions as key reaction sequence. Anticancer activities of all these derivatives were screened against IMR-32, SF-295, SKNSH, HeLa, Colon-502713, SW-620, and Hop-62 cell lines for the first time.

  DOI：

  10.1007/s00044-013-0466-y
• 作为产物：
  描述：

  (2S,3S)-2,3-epoxydecan-1-ol 在 咪唑 、 4-二甲氨基吡啶 、 Red-Al 、 四丁基氟化铵 、 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 、 mineral oil 为溶剂， 反应 34.5h， 生成 (S)-3-methoxydecan-1-ol
  参考文献：
  名称：

  Novel malyngamide structural analogs: synthesis and biological evaluation

  摘要：

  In the course of our search for new anticancer agents, a series of novel malyngamide derivatives were synthesized by sharpless asymmetric epoxidation, followed by Julia-Kocinski olefination reactions as key reaction sequence. Anticancer activities of all these derivatives were screened against IMR-32, SF-295, SKNSH, HeLa, Colon-502713, SW-620, and Hop-62 cell lines for the first time.

  DOI：

  10.1007/s00044-013-0466-y

文献信息

• A concise total synthesis of lyngbic acid, hermitamides A and B
  作者：S. Satyanarayana、B.V. Subba Reddy、R. Narender

  DOI：10.1016/j.tetlet.2014.08.125

  日期：2014.10

  A concise total syntheses of lyngbic acid, hermitamides A and B have been accomplished in a highly enantioselective manner involving CBS asymmetric reduction, hydroboration, and stereospecific Julia-Lythgoe olefination. (C) 2014 Published by Elsevier Ltd.