甘石胆酸钠盐 | 24404-83-9

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 甘石胆酸钠盐
• 中文别名: 甘氨石胆酸钠
• 英文名称: Sodium N-(carboxymethyl)-3-hydroxycholan-24-imidate
• 英文别名: sodium;(4R)-N-(carboxymethyl)-4-[(3R,5R,10S,13R,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanimidate
• CAS: 24404-83-9
• 化学式: C26H42NNaO4
• 分子量: 455.6
• InChiKey: LQKBJAKZKFBLIB-NYTIRPLLSA-M

物化性质

• 熔点：
  210-220 °C
• 溶解度：
  DMSO（微溶，超声），乙醇（微溶），甲醇（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  0.29
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  89.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Detection and Quantitation Method for Proteomics of Post-Translational Modifications
  申请人：Sichuan University

  公开号：US20200033361A1

  公开（公告）日：2020-01-30

  The present disclosure relates to the technical field of comparative proteomics, in particular to a detection and quantitation method for proteomics of post-translational modifications. With this method, the protein samples to be studied and internal standards are labeled with isobaric tandem mass tags, and tandem mass spectrometry analysis is carried out for the labeled peptide mixture, wherein the internal standard is a peptide mixture rich in post-translational modifications to be detected. Through this method, the signal of peptides containing the post-translational modifications to be detected can be amplified under the situation that mass spectrometer sensitivity is unchanged, and enrichment of the post-translational modification peptides is not needed. The probability of detecting the peptides containing the post-translational modifications to be detected by mass spectrometer and being selected for subsequent MS/MS analysis is increased.
• [EN] COMPOSITION OR FORMULATION COMPRISING ONE OR MORE 5-ALPHA-REDUCTASE INHIBITORS AND ONE OR MORE BILE ACIDS<br/>[FR] COMPOSITION OU FORMULATION COMPRENANT UN OU PLUSIEURS INHIBITEURS DE 5-ALPHA-RÉDUCTASE ET UN OU PLUSIEURS ACIDES BILIAIRES
  申请人：[en]S&R FARMACEUTICI S.P.A.

  公开号：WO2022185228A1

  公开（公告）日：2022-09-09

  The purpose of the invention is to provide a topical composition for the treatment of androgen-dependent dermatoses characterized by the association of one or more bile acids and one or more inhibitors of the 5 alpha reductase enzyme. A composition or formulation comprising one or more inhibitors of 5 alpha reductase and one or more bile acids is useful for the treatment of pathologies linked to androgenic imbalance (androgenic dermatoses) with the ability to limit the side effects of the inhibitors, of 5 alpha reductase and enhance the cytoprotective effects of bile acids.
• [EN] USE OF STOICHIOMETRIC COMBINATION OF RESVERATROL AND BILE ACIDS FOR TOPICAL TREATMENT OF NEUROGENIC INFLAMMATION AND ITCHING<br/>[FR] UTILISATION D'UNE COMBINAISON STOECHIOMÉTRIQUE DE RESVÉRATROL ET D'ACIDES BILIAIRES POUR LE TRAITEMENT TOPIQUE D'UNE INFLAMMATION NEUROGÈNE ET D'UNE DÉMANGEAISON
  申请人：[en]S&R FARMACEUTICI S.P.A.

  公开号：WO2022259179A1

  公开（公告）日：2022-12-15

  The present invention regards a method to treat symptoms associated with neurogenic inflammation such as itching, resulting for example from insect bites, or dermatological or systemic disorders. In particular, the present invention concerns a method of treatment by the peripheral administration of a salified stoichiometric complex of bile acids and resveratrol.